| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | BEFREE | MTHFR C677T polymorphisms increase DR risk within the Chinese population. | 30628508 | 2020 |
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0.080 | GeneticVariation | BEFREE | Our study suggested that the MTHFR C677T polymorphism may contribute to DR development in multiethnic groups. | 29182429 | 2018 |
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0.080 | GeneticVariation | BEFREE | Our study suggested that the MTHFR 677C/T polymorphism may contribute to DR development, especially in Asian populations. | 27517946 | 2016 |
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|
0.080 | GeneticVariation | BEFREE | Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy and diabetic retinopathy. | 23901246 | 2013 |
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0.080 | GeneticVariation | BEFREE | An updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy. | 22056717 | 2012 |
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|
0.080 | GeneticVariation | BEFREE | Overall, the meta-analysis suggested large heterogeneity between studies (p = 0.08, I(2) = 52%) and marginal association between C677T transition and the risk of developing DR: random effects odds ratio (OR) = 1.39 [95% CI (1.05, 1.83)]. | 15902512 | 2005 |
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|
0.080 | GeneticVariation | BEFREE | MTHFR gene C677T mutation associated with a predisposition to increased plasma homocysteine levels may be considered as a genetic risk factor for diabetic microangiopathy (such as DR) in Chinese patients with type 2 diabetes mellitus. | 12667409 | 2003 |
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|
0.080 | GeneticVariation | BEFREE | We investigated the relationship between diabetic retinopathy (DR) and three polymorphisms, C(-106)T in the aldose reductase (ALR2) gene, 4G/5G in the plasminogen activator inhibitor-1 (PAI-1) gene and C677T in the methylenetetrahydrofolate reductase (MTHFR) gene, in 210 Euro-Brazilian type 2 diabetic patients. | 12951282 | 2003 |