DisGeNET - a database of gene-disease associations

Diabetic Retinopathy, C0011884

Variant: rs759853 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs759853

AKR1B1

0.040

GeneticVariation

BEFREE

CONCLUSIONS ALR2 rs759853 and SDH rs2055858 polymorphisms were respectively associated with a higher and lower risk of diabetic retinopathy.

31539366

2019

dbSNP:

rs759853

AKR1B1

0.040

GeneticVariation

BEFREE

AKR1B1 polymorphism rs759853 may inhibit the occurrence of DR in patients with type 1 DM.

30201105

2018

dbSNP:

rs759853

AKR1B1

0.040

GeneticVariation

BEFREE

Present study aimed to investigate the association of aldose reductase (AKR1B1) gene polymorphism (-106C>T; rs759853) with diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) patients from north India.

27640118

2016

dbSNP:

rs759853

AKR1B1

0.040

GeneticVariation

BEFREE

The T allele of the AKR1B1 promoter rs759853 variant is also significantly protective against diabetic retinopathy in type 1 diabetes (0.5 [0.35-0.71], P = 1.00 x 10(-4)), regardless of ethnicity.

19587357

2009