|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7).
|
30407486 |
2019 |
|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population.
|
31839644 |
2019 |
|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis.
|
27001215 |
2016 |
|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and H. pylori-negatives (19.5%) (p < .001).
|
25582162 |
2015 |
|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Genomic DNA from 603 Spanish patients with primary GC, 139 with DU and 675 healthy controls was typed for the PSCA rs2294008C>T polymorphism by PCR-TaqMan assays.
|
25721731 |
2015 |
|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians.
|
25721731 |
2015 |
|
rs2294008
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
rs2294008
|
|
C |
0.860 |
GeneticVariation |
GWASCAT |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |
|
rs2294008
|
|
C |
0.860 |
GeneticVariation |
GWASDB |
The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)).
|
22387998 |
2012 |