Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10489265
rs10489265
0.010 GeneticVariation BEFREE To replicate the association, two single-nucleotide polymorphisms (SNPs: rs2205960 and rs10489265) were genotyped in 814 SLE patients. 23936824

2013

dbSNP: rs1051169
rs1051169
0.010 GeneticVariation BEFREE Stratified analyses showed that the rs1051169 polymorphism was associated with an increased risk of neurologic disorder in SLE patients (C vs. G: OR=1.78, 95% CI, 1.22-2.59, p=0.003; GC vs. GG: OR=2.33, 95% CI, 1.14-4.77, P=0.019; CC vs. GG: OR=3.02, 95% CI, 1.39-6.53, p=0.004; CC+GC vs. GG: OR=2.57, 95% CI=1.31-5.04, p=0.005). 31271591

2020

dbSNP: rs10516487
rs10516487
0.020 GeneticVariation BEFREE This study implies that rs10516487 and rs17266594 polymorphisms might contribute to individual susceptibility to SLE and influence the ANA/SSA autoantibody response in SLE patients in Chinese population. 21078628

2011

dbSNP: rs10516487
rs10516487
0.020 GeneticVariation BEFREE SLE was associated with frequency of rs548234 (P = 0.010; odds ratio [OR] = 1.298), rs2736340 (P = 2.47 × 10<sup>-5</sup> ; OR = 1.574) and rs10516487 (P = 0.002; OR = 0.642). 26420661

2016

dbSNP: rs1061622
rs1061622
0.010 GeneticVariation BEFREE Lack of association between the Met196Arg polymorphism in the TNFR2 gene and autoimmune diseases accompanied by vasculitis including SLE in Japanese. 11169260

2001

dbSNP: rs12720270
rs12720270
0.010 GeneticVariation BEFREE SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500. 31434951

2019

dbSNP: rs12720356
rs12720356
0.010 GeneticVariation BEFREE SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500. 31434951

2019

dbSNP: rs13277113
rs13277113
BLK
0.010 GeneticVariation BEFREE We observed more frequent heterozygous GA genotypic pattern (rs13277113) in our SLE patients compared to that in controls; and it was associated with disease flares. 27864698

2017

dbSNP: rs17266594
rs17266594
0.010 GeneticVariation BEFREE This study implies that rs10516487 and rs17266594 polymorphisms might contribute to individual susceptibility to SLE and influence the ANA/SSA autoantibody response in SLE patients in Chinese population. 21078628

2011

dbSNP: rs1799983
rs1799983
0.010 GeneticVariation BEFREE Glu298Asp eNOS polymorphism is not associated with SLE. 19318399

2009

dbSNP: rs2069705
rs2069705
0.010 GeneticVariation BEFREE SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model. 19919944

2010

dbSNP: rs2069718
rs2069718
0.010 GeneticVariation BEFREE SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model. 19919944

2010

dbSNP: rs2243188
rs2243188
0.010 GeneticVariation BEFREE The minor C allele of rs2243188, relative to the major A allele, appeared to have a significantly lower frequency in SLE patients (31.0%) as compared with controls (35.5%) (χ(2) = 5.19, p = 0.023). 24819332

2014

dbSNP: rs2304256
rs2304256
0.010 GeneticVariation BEFREE SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500. 31434951

2019

dbSNP: rs231775
rs231775
0.010 GeneticVariation BEFREE The CTLA4 +49 A/G (rs231775) polymorphism influences susceptibility to SLE in South Indian Tamils. 24758310

2014

dbSNP: rs2397084
rs2397084
0.010 GeneticVariation BEFREE IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival. 26515887

2016

dbSNP: rs2430561
rs2430561
0.010 GeneticVariation BEFREE SLE susceptibility association was significant with rs2069705 in the promoter (adjusted OR 2.27, p=0.0024) and marginal with rs3181032 in the promoter (p=0.037), rs2430561 in intron 1 (p=0.022) and rs2069718 in intron 3 (p=0.026) in a recessive genetic model. 19919944

2010

dbSNP: rs2476601
rs2476601
0.030 GeneticVariation BEFREE PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results. 24985973

2014

dbSNP: rs2476601
rs2476601
0.030 GeneticVariation BEFREE Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete. 21543514

2011

dbSNP: rs2476601
rs2476601
0.030 GeneticVariation BEFREE Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. 15273934

2004

dbSNP: rs2736340
rs2736340
0.010 GeneticVariation BEFREE SLE was associated with frequency of rs548234 (P = 0.010; odds ratio [OR] = 1.298), rs2736340 (P = 2.47 × 10<sup>-5</sup> ; OR = 1.574) and rs10516487 (P = 0.002; OR = 0.642). 26420661

2016

dbSNP: rs280500
rs280500
0.010 GeneticVariation BEFREE SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500. 31434951

2019

dbSNP: rs28362930
rs28362930
0.010 GeneticVariation BEFREE The allele frequency of G (rs28362930) was higher in S</span>LE patients with renal disorder. 31394943

2019

dbSNP: rs2910164
rs2910164
0.010 GeneticVariation BEFREE The G and C allele frequencies of rs2</span>910164 were 39 and 61% in SLE patients, but 36 and 64% in healthy group (P = 0.990), respectively. 20845080

2011

dbSNP: rs3077
rs3077
0.010 GeneticVariation BEFREE In conclusion, HLA-DP polymorphisms (rs3077 and rs9277535) were associated with SLE susceptibility and the levels of some inflammatory cytokines in SLE patients. 28094303

2017