Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.080 | GeneticVariation | BEFREE | The G2677T T and C3435T T alleles as well as the TT, CTT and TTT haplotypes seemed to be significantly associated with drug-resistance epilepsy in our population. | 29198163 | 2018 |
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0.080 | GeneticVariation | BEFREE | The association between the non-synonymous polymorphism G2677T/A in the coding region of the ABCB1 gene, and the risk of resistance to anti-epileptic drugs (AEDs) in epilepsy remains controversial. | 26220385 | 2015 |
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0.080 | GeneticVariation | BEFREE | rs776746 and rs15524 in the CYP3A5 gene tend to affect CBZ metabolism, and rs2032582, rs10234411 in the ABCB1 gene may contribute to inter-individual variation in CBZ and in CBZ-E transport among patients with epilepsy using CBZ in combination with PHT or PB. | 26421491 | 2015 |
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0.080 | GeneticVariation | BEFREE | Our results suggest that MDR1 C3435T and G2677T/A polymorphisms are not associated with AED resistance in Turkish epileptic patients. | 24213830 | 2014 |
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0.080 | GeneticVariation | BEFREE | In this study, we analyzed whether the three single nucleotide polymorphisms (C1236T, G2677T/A, and C3435T) in the ABCB1 gene were associated with pharmacoresistant epilepsy in a western Chinese pediatric population. | 21420937 | 2011 |
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0.080 | GeneticVariation | BEFREE | No significant association was found between G2677T/A polymorphism and epilepsy drug resistance in the different subgroups of patients. | 21636342 | 2011 |
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0.080 | GeneticVariation | BEFREE | Our aim was to investigate the effect of the 1236C>T(rs1128503), 2677G>T/A(rs2032582), and 3435C>T(rs1045642) single-nucleotide polymorphisms of ABCB1 (or MDR1) on drug resistance in north Indian patients with epilepsy. | 18812236 | 2009 |
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0.080 | GeneticVariation | BEFREE | Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification. | 17924830 | 2007 |