Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11552822
rs11552822
0.700 GeneticVariation UNIPROT

dbSNP: rs747621669
rs747621669
0.700 GeneticVariation UNIPROT

dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE <b>Background</b>: TNF-α-308G/A (rs1800629) polymorphism has been previously implicated in the susceptibility to esophageal cancer, but results of these studies remained controversial or ambiguous. 30854115

2019

dbSNP: rs11548103
rs11548103
0.010 GeneticVariation BEFREE <i>S100A14</i> rs11548103 G>A polymorphism is associated with a decreased risk of esophageal cancer in a Chinese population. 29156846

2017

dbSNP: rs1052133
rs1052133
0.030 GeneticVariation BEFREE Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population. 11307145

2001

dbSNP: rs61748181
rs61748181
0.010 GeneticVariation BEFREE A279T induces telomere dysfunction and inhibits non-canonical telomerase activity in esophageal cancer cells. 24983628

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A meta-analysis was performed to obtain summary estimated odd ratios and 95% confidence intervals of folate intake and MTHFR C677T for esophageal cancer. 21517266

2011

dbSNP: rs4462560
rs4462560
0.010 GeneticVariation BEFREE A NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy. 24022861

2013

dbSNP: rs3765524
rs3765524
T 0.820 GeneticVariation GWASDB A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010

dbSNP: rs3765524
rs3765524
T 0.820 GeneticVariation GWASCAT A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010

dbSNP: rs738722
rs738722
T 0.810 GeneticVariation GWASCAT A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010

dbSNP: rs738722
rs738722
T 0.810 GeneticVariation GWASDB A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010

dbSNP: rs3781264
rs3781264
C 0.700 GeneticVariation GWASDB A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010

dbSNP: rs4072037
rs4072037
A 0.700 GeneticVariation GWASDB A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010

dbSNP: rs2274223
rs2274223
0.900 GeneticVariation BEFREE A single-nucleotide polymorphism (rs2274223: A5780G:His1927Arg) in the phospholipase C epsilon gene (PLCϵ) was recently identified as a susceptibility locus for esophageal cancer in Chinese subjects. 23390063

2013

dbSNP: rs1229984
rs1229984
0.840 GeneticVariation BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924

2010

dbSNP: rs201745983
rs201745983
0.010 GeneticVariation BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924

2010

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE ALDH2, MTHFR C677T, CYP1A1 Ile/Val, CYP1A1MspI, CYP2E1, GSTP1, GSTM1 and GSTT1 were examined by meta-analyses and significant relations were found between ALDH2*1*2 and the CYP1A1 Val allele and increased risk of esophageal cancer. 17674367

2007

dbSNP: rs879253942
rs879253942
0.010 GeneticVariation BEFREE ALDH2, MTHFR C677T, CYP1A1 Ile/Val, CYP1A1MspI, CYP2E1, GSTP1, GSTM1 and GSTT1 were examined by meta-analyses and significant relations were found between ALDH2*1*2 and the CYP1A1 Val allele and increased risk of esophageal cancer. 17674367

2007

dbSNP: rs13181
rs13181
0.020 GeneticVariation BEFREE Although no significant risk associations were observed for rs13181, further mini meta-analysis with our and 18 other published studies of 5,012 cases and 8,238 controls found evidence of an association between the rs13181 variant G allele and esophageal cancer risk (TG/GG vs. TT, OR = 1.17; 95% CI = 1.02-1.33). 25209371

2014

dbSNP: rs671
rs671
0.880 GeneticVariation BEFREE Among male daily consumers, the HRs (95% CIs) for EC associated with 15g/d of alcohol were 1.28 (1.15, 1.44) for "soon" response [vs. other responses: 1.12 (1.09, 1.15); p<sub>interaction</sub>  = 0.047; n = 36,401, 425 EC cases] and 1.41 (1.08, 1.82) for rs671 GA [vs. GG: 1.16 (1.06, 1.27); p<sub>interaction</sub>  = 0.493; n = 6,607, 80 EC cases]. 29707772

2018

dbSNP: rs1042522
rs1042522
0.080 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014

dbSNP: rs1131691014
rs1131691014
0.070 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014

dbSNP: rs878854066
rs878854066
0.070 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014

dbSNP: rs6214
rs6214
0.010 GeneticVariation BEFREE An OR of 1.54 (95% CI, 1.05-2.27) was found for EC for genotype AA of rs6214. 24608110

2014