Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1000668
rs1000668
TMC1
0.700 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs10052657
rs10052657
PDE4D
C 0.700 GeneticVariation GWASCAT Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993

2011
dbSNP: rs10058728
rs10058728
CSNK1A1
T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. 21642993

2011
dbSNP: rs10069690
rs10069690
TERT
0.010 GeneticVariation BEFREE Of the four SNPs examined, rs10069690 and rs2242652 were correlated with esophageal cancer risk. 28060765

2017
dbSNP: rs1014867
rs1014867
FAT4
0.010 GeneticVariation BEFREE These findings indicate that the nonsynonymous variants rs1014867 (Pro4972Ser) and rs1039808 (Ala807Val) of FAT4 may contribute to esophageal cancer susceptibility. 23319386

2013
dbSNP: rs10186527
rs10186527
FLACC1
0.700 GeneticVariation GWASDB Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. 22323360

2012
dbSNP: rs10191793
rs10191793
ST6GAL2
0.700 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs10197246
rs10197246
FLACC1
0.700 GeneticVariation GWASDB Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. 22323360

2012
dbSNP: rs10201587
rs10201587
FLACC1
0.700 GeneticVariation GWASDB Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. 22323360

2012
dbSNP: rs10274928
rs10274928
JAZF1
0.700 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs1035142
rs1035142
FLACC1
0.010 GeneticVariation BEFREE Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population. 24464182

2014
dbSNP: rs1039808
rs1039808
FAT4
0.010 GeneticVariation BEFREE We also observed a borderline significant association between rs1039</span>808 (Ala807Val) and esop</span>hageal cancer</span> risk (OR=0.90, 95% CI=0.82-1.00; p=0.050), which was more prominent in non-drinkers (OR=0.82, 95% CI=0.71-0.94; p=6.53 × 10(-3)). 23319386

2013
dbSNP: rs1042026
rs1042026
ADH1B
0.800 GeneticVariation GWASDB Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. 20833657

2010
dbSNP: rs1042026
rs1042026
ADH1B
0.800 GeneticVariation GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs1042026
rs1042026
ADH1B
0.800 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE Association of the p53 Arg72Pro polymorphism with esophageal cancer in Chinese populations: a meta-analysis. 26345834

2015
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. 20827430

2010
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE Crude odds ratios (ORs) with 95% confidence intervals (CIs) were assessed for EC risk associated with TP53 Arg72Pro polymorphism using fixed- and random-effects models. 21448430

2011
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE This study aimed to evaluate the prognostic significance of two functional single nucleotide polymorphisms (SNP) in the p53 pathway (p53 Arg72Pro and MDM2 T309G) in patients with esophageal cancer, and to determine the importance of histologic subtype in the SNP-outcome relationships. 19383811

2009
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE Telomeres of patients with minor genotype CC of rs12951053 and GG of rs1042522 were significantly shorter compared to patients with other genotypes of this single nucleotide polymorphism in esophageal cancer tissue. 23124483

2013
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significantly associated with the Pro variant of TP53 Arg72Pro in three genetic comparison models [odds ratio (OR)Pro vs. Arg=1.21, 95% confidence interval (CI): 1.05-1.39, POR=0.009; ORDominant genetic model=1.22, 95% CI: 1.09-1.37, POR=0.001; ORHomozygote model=1.40, 95% CI: 1.05-1.87, POR=0.024]. 20389250

2010
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE In the stratified analysis by ethnicity, the data suggested that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in the Asian group. 23844939

2013
dbSNP: rs1042522
rs1042522
TP53
0.080 GeneticVariation BEFREE Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susceptibility. 25339039

2014
dbSNP: rs10454127
rs10454127
FLACC1
0.700 GeneticVariation GWASDB Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. 22323360

2012
dbSNP: rs1045642
rs1045642
ABCB1
0.010 GeneticVariation BEFREE Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally advanced esophageal cancer. 21332314

2011