Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis provides evidence that the MTHFR C677T polymorphism contributes to esophageal cancer development in Chinese populations. 24606463

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We conducted a meta-analysis to investigate the association of MTHFR C677T and folate intake with esophageal cancer risk. 23534726

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese. 23803097

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our findings supports the hypothesis that high folate intake and active MTHFR C677T polymorphism may exert protective roles in the prognosis of esophageal cancer in the Chinese population. 22524840

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A meta-analysis was performed to obtain summary estimated odd ratios and 95% confidence intervals of folate intake and MTHFR C677T for esophageal cancer. 21517266

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer. 22292644

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The alleles ALDH2 and MTHFR C677T were critical for determining individual susceptibility to esophageal cancer. 21672255

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We report a pooled analysis of 5 studies on the association of MTHFR C677T polymorphism and esophageal cancer, including 725 cases and 1531 controls. 18840514

2009

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population. 19058336

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE ALDH2, MTHFR C677T, CYP1A1 Ile/Val, CYP1A1MspI, CYP2E1, GSTP1, GSTM1 and GSTT1 were examined by meta-analyses and significant relations were found between ALDH2*1*2 and the CYP1A1 Val allele and increased risk of esophageal cancer. 17674367

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk. 15790587

2005