Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs151344517
rs151344517
AFG3L2 ; TUBB6 ; LOC107985154
T 0.700 CausalMutation CLINVAR Missense mutations in the AFG3L2 proteolytic domain account for ∼1.5% of European autosomal dominant cerebellar ataxias. 20725928

2010
dbSNP: rs1057518925
rs1057518925
COL6A2
G 0.700 GeneticVariation CLINVAR

dbSNP: rs1057523354
rs1057523354
COL4A1
A 0.700 CausalMutation CLINVAR

dbSNP: rs121918459
rs121918459
PTPN11
G 0.700 CausalMutation CLINVAR

dbSNP: rs1331463984
rs1331463984
TRAF7
A 0.700 CausalMutation CLINVAR

dbSNP: rs139194636
rs139194636
WARS2
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1553315329
rs1553315329
SPAST
T 0.700 CausalMutation CLINVAR

dbSNP: rs1553621496
rs1553621496
UNC80
G 0.700 GeneticVariation CLINVAR

dbSNP: rs1554317002
rs1554317002
CDK13 ; LOC112267983
T 0.700 GeneticVariation CLINVAR

dbSNP: rs1555366607
rs1555366607
SPTB
G 0.700 CausalMutation CLINVAR

dbSNP: rs1555889984
rs1555889984
RUNX1
A 0.700 GeneticVariation CLINVAR

dbSNP: rs1559931177
rs1559931177
QRICH1
A 0.700 CausalMutation CLINVAR

dbSNP: rs1560755661
rs1560755661
TBCK
A 0.700 CausalMutation CLINVAR

dbSNP: rs181109321
rs181109321
TTPA
T 0.700 GeneticVariation CLINVAR

dbSNP: rs551423795
rs551423795
MUSK
G 0.700 GeneticVariation CLINVAR

dbSNP: rs756877019
rs756877019
MUSK
C 0.700 GeneticVariation CLINVAR

dbSNP: rs757600616
rs757600616
WARS2
A 0.700 GeneticVariation CLINVAR

dbSNP: rs864321670
rs864321670
ALDH18A1
T 0.700 CausalMutation CLINVAR

dbSNP: rs869312697
rs869312697
ARID1B
T 0.700 CausalMutation CLINVAR

dbSNP: rs1800562
rs1800562
HFE ; LOC108783645
0.020 GeneticVariation BEFREE In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men. 30657865

2019
dbSNP: rs1045642
rs1045642
ABCB1
0.020 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018
dbSNP: rs1045642
rs1045642
ABCB1
0.020 GeneticVariation BEFREE i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness. 22672924

2012
dbSNP: rs16944
rs16944
IL1B
0.020 GeneticVariation BEFREE IL1B-511 (rs16944) genotype did not significantly predict changes in fatigue (p values >0.46). 22475653

2012
dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE Patients with the TNFA-308 (rs1800629) G/A genotype showed greater increases in fatigue severity than the G/G genotype (p = 0.02). 22475653

2012
dbSNP: rs1800795
rs1800795
IL6 ; STEAP1B ; IL6-AS1
0.020 GeneticVariation BEFREE Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and duration than the G/G genotype (p values ≤ 0.05), although inclusion of age, race, and baseline depressive symptomatology in the model attenuated these relationships (p values ≤ 0.09). 22475653

2012