rs151344517
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Missense mutations in the AFG3L2 proteolytic domain account for ∼1.5% of European autosomal dominant cerebellar ataxias.
|
20725928 |
2010 |
rs1057518925
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1057523354
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121918459
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1331463984
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs139194636
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1553315329
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1553621496
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1554317002
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1555366607
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1555889984
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1559931177
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1560755661
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs181109321
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs551423795
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs756877019
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs757600616
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs864321670
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs869312697
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs1800562
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men.
|
30657865 |
2019 |
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue.
|
29885788 |
2018 |
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
IL1B-511 (rs16944) genotype did not significantly predict changes in fatigue (p values >0.46).
|
22475653 |
2012 |
rs1800629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with the TNFA-308 (rs1800629) G/A genotype showed greater increases in fatigue severity than the G/G genotype (p = 0.02).
|
22475653 |
2012 |
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and duration than the G/G genotype (p values ≤ 0.05), although inclusion of age, race, and baseline depressive symptomatology in the model attenuated these relationships (p values ≤ 0.09).
|
22475653 |
2012 |