rs1057519902
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Exon sequencing has identified a mutation in K27M of the histone H3.3 gene (H3F3A K27M and G34R/V) in about 20% of pediatric glioblastomas, but it remains to be seen whether these mutations can be considered specific for pediatric diffuse high-grade astrocytomas or also occur in other pediatric brain tumors.
|
23429371 |
2013 |
rs1553260624
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Exon sequencing has identified a mutation in K27M of the histone H3.3 gene (H3F3A K27M and G34R/V) in about 20% of pediatric glioblastomas, but it remains to be seen whether these mutations can be considered specific for pediatric diffuse high-grade astrocytomas or also occur in other pediatric brain tumors.
|
23429371 |
2013 |
rs1057519902
|
|
|
0.740 |
GeneticVariation |
BEFREE |
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V).
|
23414300 |
2013 |
rs1553260624
|
|
|
0.040 |
GeneticVariation |
BEFREE |
H3F3A mutations are seen in ∼30% of pediatric glioblastoma (GBMs) and involve either the lysine residue at position 27 (K27M) or glycine at position 34 (G34R/V).
|
23414300 |
2013 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Histologically, the tumor was considered to be glioblastoma; however, a part of the tumor exhibiting low proliferative activity appeared to be consistent with long-standing H3 K27M-mutant tumors in the literature.Another case was a 69-year-old male.
|
28547652 |
2017 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Histone H3.3 (H3F3A) mutation in the codon for lysine 27 (K27M) has been found as driver mutations in pediatric glioblastoma and has been suggested to play critical roles in the pathogenesis of thalamic gliomas and diffuse intrinsic pontine gliomas.
|
27392443 |
2016 |
rs1057519902
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Histopathologically, the four G34R-mutant cases included three glioblastomas and one astroblastoma.
|
28447171 |
2017 |
rs1553260624
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Histopathologically, the four G34R-mutant cases included three glioblastomas and one astroblastoma.
|
28447171 |
2017 |
rs1057519902
|
|
C |
0.740 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Mutated IDH1 R132H protein and H3F3A K27M mutations indicate that a substantial number of GBMc are "metastatic" or "diaschismatic" lesions.
|
30203362 |
2018 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our results indicate that H3F3A K27M mutant GBMs show decreased H3K27me3 that may be of both diagnostic and biological relevance.
|
23414300 |
2013 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
rs1057519902
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
rs1553260624
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Recent studies on high-grade pediatric GBM have identified two recurrent mutations (K27M and G34R/V) in genes encoding histone H3 (H3F3A for H3.3 and HIST1H3B for H3.1).
|
23907119 |
2013 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The K27M mutation occurred in 35 of 129 glioblastomas (27.1%) and in 5 of 28 (17.9%) anaplastic astrocytomas.
|
23429371 |
2013 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These results demonstrate that we have developed a new reliable procedure for detecting the H3F3A K27M mutation in pediatric glioblastoma patient samples.
|
26376656 |
2016 |
rs1057519903
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These results suggest that immunohistochemical detection of H3.3 K27M is a sensitive and specific surrogate for the H3F3A K27M mutation and defines a prognostically poor subset of pediatric GBM.
|
25200322 |
2014 |