|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this study, we generated clonal U87 and U251 glioma cell lines overexpressing the R132H mutant protein (IDH1-R132H).
|
25283382 |
2015 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Small-size DNA (150-250 base pairs) was extracted from the plasma of 31 controls and 80 patients with glioma with known IDH1(R132H) status and correlated with MRI data.
|
23035067 |
2012 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The isocitrate dehydrogenase 1 (IDH1) R132H mutation is the most common mutation in World Health Organization (WHO) grade II gliomas, reported to be expressed in 70-80%, but only 5-10% of high grade gliomas.
|
24903073 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
<i>IDH1</i> mutations only affected brainstem gliomas (6/24 vs 0/78; <i>p</i> = 7.5 × 10<sup>-5</sup>), were mostly non-R132H (contrasting with hemispheric gliomas, <i>p</i> = 0.0001), and were associated with longer survival (54 vs 12 months).
|
29728520 |
2018 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The R132H mutation in isocitrate dehydrogenase 1 (IDH1-R132H) is associated with better prognosis in glioma patients.
|
29115585 |
2018 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results indicate the usefulness of assessing the R132H IDH1 mutation in glioma patients: the presence or absence of the R132H mutation can help pathologists to distinguish pilocytic astrocytomas (IDH1 WT) from diffuse ones (R132H IDH1/WT).
|
23934769 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This study analyses a series of 184 glioma cases in a tissue microarray (TMA)-based approach to assess the frequency of R132H point mutations in formalin-fixed, paraffin-embedded tissue samples.
|
23361281 |
2013 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Additionally, 5-aza enhances the therapeutic effect of the DNA damaging agent TMZ in both subcutaneous and orthotopic PDX models of IDH1 R132H mutant glioma.
|
30184215 |
2019 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The IDH1-R132H mutation predicts a better clinical outcome for glioma patients, and the expression of IDH1-R132H correlates with a favorable outcome in patients with brain tumors.
|
27655638 |
2016 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Using murine glioma progenitor cells, we demonstrate that IDH1(R132H) exerts a growth-inhibitory effect that is paralleled by deficiency in metabolic flux from glucose and glutamine to lipids.
|
25225364 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Further, overexpression of β-catenin in IDH1-R132H glio</span>ma cells restored the cellular phenotype induced by this mutation.
|
26860959 |
2016 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We earlier established a monoclonal antibody (mAb), IMab-1, which is specific for R132H-containing IDH1 (IDH1-R132H), the most frequent IDH1 mutation in gliomas.
|
21352804 |
2011 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Sequencing for rare IDH mutations is advised for A,NOS and OA,NOS groups, but not for the IDH1(R132H)-non-mutant diffuse gliomas with 1p/19q co-deletion.
|
28801347 |
2018 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
|
31292202 |
2019 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, the association of a C-terminally truncated form of αB-crystallin protein with the IDH1(R132H) mutation is a novel finding that could impact apoptosis and stress response in IDH1 mutant glioma.
|
24473683 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations.
|
28445981 |
2017 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This novel series of IDH1(R132H) inhibitors have potential to be further developed for the treatment of glioma with IDH1 mutation.
|
29792149 |
2018 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Interestingly, non-p.R132H mutations segregate in distinct histological and molecular subtypes of glioma.
|
20077503 |
2010 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This case suggests that 1p/19q co-deletion may rarely precede IDH1 mutations or that IDH1 mutations may be secondarily lost, as demonstrated by IDH1-R132H positive and negative cells in a glioma with diffuse 1p/19q co-deletion.
|
25907263 |
2016 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, we established an anti-IDH1(R132H)-specific monoclonal antibody IMab-1, which should be significantly useful for diagnosis and biological evaluation of mutation-bearing gliomas.
|
19818334 |
2009 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway.
|
28427200 |
2017 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This glioma xenograft is the first to display a pure oligodendroglioma histology and expression of R132H.
|
23527265 |
2013 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We developed and validated a new real-time quantitative polymerase chain reaction (PCR) assay for single-step detection of IDH1 R132H and 11 rare IDH1/2 mutations in formalin-fixed paraffin-embedded (FFPE) glioma samples.
|
24889502 |
2014 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For this study, 164 cases of glioma were evaluated immunohistochemically for IDH1 mutations (R132H and R132S) using anti-IDH1 mAbs (HMab-1 and SMab-1).
|
22396072 |
2012 |
|
rs121913500
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our results suggest that the pathogenesis of multicentric gliomas is different from the mutant IDH1-R132H pathogenesis of lower-grade glioma and secondary glioblastomas.
|
27553586 |
2017 |