|
rs121913500
|
|
|
0.800 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs121913499
|
|
|
0.720 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs104894156
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs1064794096
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs1554893792
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs63751110
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs786202398
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs104894104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to test the candidacy of p16beta as a glioma suppressor, we replaced p16(INK4a), p15(INK4b) and p16beta wild-type as well as a series of seven glioma-derived p16beta alleles (R87H, A112V, R120H, A121V, G125R, A128A and A128V), into glioma cell lines that had either CDKN2A-/RB+ (U-87MG and U-251MG) or CDKN2A+/RB- (LN-319) endogenous backgrounds and demonstrated that p16beta can act as a functional glioma cell growth suppressor.
|
9366518 |
1997 |
|
rs1431316232
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to test the candidacy of p16beta as a glioma suppressor, we replaced p16(INK4a), p15(INK4b) and p16beta wild-type as well as a series of seven glioma-derived p16beta alleles (R87H, A112V, R120H, A121V, G125R, A128A and A128V), into glioma cell lines that had either CDKN2A-/RB+ (U-87MG and U-251MG) or CDKN2A+/RB- (LN-319) endogenous backgrounds and demonstrated that p16beta can act as a functional glioma cell growth suppressor.
|
9366518 |
1997 |
|
rs749124997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, ectopic expression of wild type PTEN, but not the PTEN(G129R) mutant, in PTEN-mutant gliomas markedly sensitizes these cells to irradiation and to CD95-ligand (CD95L)-induced apoptosis.
|
10435616 |
1999 |
|
rs786204929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, ectopic expression of wild type PTEN, but not the PTEN(G129R) mutant, in PTEN-mutant gliomas markedly sensitizes these cells to irradiation and to CD95-ligand (CD95L)-induced apoptosis.
|
10435616 |
1999 |
|
rs17006625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the frequency of the Asn386Ser allele that contained Ser386 in glioma patients was not statistically different from its frequency in individuals without disease, and no significant association was observed between the PCAF polymorphisms and the presence or absence of p53 mutations in the tumors.
|
10896202 |
2000 |
|
rs1695
|
|
|
0.040 |
GeneticVariation |
BEFREE |
There was evidence of supermultiplicativity of the joint effect of GSTP1 I105V and CYP2E1 RsaI variants on both glioma and acoustic neuroma, even following adjustment of estimates toward a common prior distribution using hierarchical regression models.
|
12540498 |
2003 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men.
|
15947495 |
2005 |
|
rs13181
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped constitutive variants ERCC1 C8092A and ERCC2 K751Q and R156R in approximately 450 adults with glioma and 500 controls from two independent population-based series, uniformly reviewed patients' tumors to determine histopathologic category, and determined a variety of tumor markers among astrocytic tumors.
|
16212814 |
2005 |
|
rs1625895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six hundred and eighty glioma cases (298 glioblastoma (GBM)), 503 meningioma cases, and 1555 controls recruited in the Nordic-UK Interphone study, were analysed in association with three polymorphisms in p53 (rs2287499, rs1042533, rs1625895) and five polymorphisms in ATM ( rs228599, rs3092992, rs664143, rs170548, rs3092993).
|
17151932 |
2007 |
|
rs3092993
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six hundred and eighty glioma cases (298 glioblastoma (GBM)), 503 meningioma cases, and 1555 controls recruited in the Nordic-UK Interphone study, were analysed in association with three polymorphisms in p53 (rs2287499, rs1042533, rs1625895) and five polymorphisms in ATM ( rs228599, rs3092992, rs664143, rs170548, rs3092993).
|
17151932 |
2007 |
|
rs3770502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that, in the single-locus analysis, glioma risk was statistically significantly associated with three XRCC5 tSNPs (SNP1 rs828704, SNP6 rs3770502 and SNP7 rs9288516, P = 0.005, 0.042 and 0.003, respectively), one XRCC6 tSNP (SNP4 rs6519265, P = 0.044) but none of XPCC7 tSNPs.
|
17389609 |
2007 |
|
rs6519265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that, in the single-locus analysis, glioma risk was statistically significantly associated with three XRCC5 tSNPs (SNP1 rs828704, SNP6 rs3770502 and SNP7 rs9288516, P = 0.005, 0.042 and 0.003, respectively), one XRCC6 tSNP (SNP4 rs6519265, P = 0.044) but none of XPCC7 tSNPs.
|
17389609 |
2007 |
|
rs828704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that, in the single-locus analysis, glioma risk was statistically significantly associated with three XRCC5 tSNPs (SNP1 rs828704, SNP6 rs3770502 and SNP7 rs9288516, P = 0.005, 0.042 and 0.003, respectively), one XRCC6 tSNP (SNP4 rs6519265, P = 0.044) but none of XPCC7 tSNPs.
|
17389609 |
2007 |
|
rs9288516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that, in the single-locus analysis, glioma risk was statistically significantly associated with three XRCC5 tSNPs (SNP1 rs828704, SNP6 rs3770502 and SNP7 rs9288516, P = 0.005, 0.042 and 0.003, respectively), one XRCC6 tSNP (SNP4 rs6519265, P = 0.044) but none of XPCC7 tSNPs.
|
17389609 |
2007 |
|
rs2308321
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the population based San Francisco Adult Glioma study, we evaluated associations between XRCC1 Arg399Gln, MGMT Leu84Phe, and MGMT Ile143Val polymorphisms with glioma risk among white cases (n = 441 to 453) and controls (n = 487 to 526).
|
17898525 |
2007 |
|
rs2243248
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively).
|
17916900 |
2007 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively).
|
17916900 |
2007 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In this first assessment of the role of TP53 Arg72Pro polymorphism in a large series of Portuguese glioma tumors, no association was observed with glioma susceptibility or overall survival, except for patients submitted to adjuvant therapy.
|
18068527 |
2008 |