Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11979158
rs11979158
A 0.850 GeneticVariation GWASCAT Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21. 29743610

2018

dbSNP: rs11979158
rs11979158
0.850 GeneticVariation BEFREE In addition, rs11506105 was significantly associated with an increased risk of glioma in both Asians and Caucasians, and rs11979158 decreased the risk of glioma in Caucasians. 29156842

2017

dbSNP: rs11979158
rs11979158
0.850 GeneticVariation BEFREE Additionally, subgroup analysis by stages of glioma found that variation of rs11979158 had stronger relationship with high-grade (OR = 1.32, 95 %CI = 1.19-1.45) than low-grade glioma (OR = 1.12, 95 % CI = 1.03-1.21). 26243184

2016

dbSNP: rs11979158
rs11979158
0.850 GeneticVariation BEFREE Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). 23161787

2013

dbSNP: rs11979158
rs11979158
0.850 GeneticVariation BEFREE Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively). 21531791

2011

dbSNP: rs11979158
rs11979158
A 0.850 GeneticVariation GWASCAT Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively). 21531791

2011

dbSNP: rs11979158
rs11979158
A 0.850 GeneticVariation GWASDB Using these data, we demonstrate two statistically independent associations between glioma and rs11979158 and rs2252586, at 7p11.2 which encompasses the EGFR gene (population-corrected statistics, P(c) = 7.72 × 10(-8) and 2.09 × 10(-8), respectively). 21531791

2011

dbSNP: rs11979158
rs11979158
0.850 GeneticVariation BEFREE Seven independent chromosomal loci have robustly been associated with glioma risk: 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1), and two loci at 7p11.2 (rs11979158 and rs2252586, EGFR). 21825990

2011

dbSNP: rs723527
rs723527
A 0.700 GeneticVariation GWASCAT Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 28346443

2017

dbSNP: rs59060240
rs59060240
T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies multiple susceptibility loci for glioma. 26424050

2015

dbSNP: rs730437
rs730437
0.040 GeneticVariation BEFREE The results showed a significant positive association between rs730437/rs845552 and glioma risk in Asians, and a significant negative association between them in Caucasians. 29156842

2017

dbSNP: rs730437
rs730437
0.040 GeneticVariation BEFREE These data suggest that five EGFR SNPs (rs11506105, rs3752651, rs1468727, rs845552 and rs730437) correlated with glioma patient prognosis, and should be furthered validated in studies of ethnically diverse patients. 27437777

2016

dbSNP: rs730437
rs730437
0.040 GeneticVariation BEFREE For rs730437, we found both the AA genotype (p=0.011) and A allele frequency (p=0.003; OR=0.703; 95% CI: 0.558-0.886) were significantly lower in the glioma patients than in the control subjects, respectively. 25514356

2015

dbSNP: rs730437
rs730437
0.040 GeneticVariation BEFREE We identified two susceptibility tSNPs in the EGFR gene that were potentially associated with an increased risk of glioma (rs730437, p = 0.016; OR: 1.32; 95%CI: 1.05-1.66 and rs1468727, p = 0.008; OR: 1.31; 95%CI: 1.04-1.65). 22662167

2012

dbSNP: rs1468727
rs1468727
0.030 GeneticVariation BEFREE We found that the CC genotype of rs1468727 was more common in the glioma group than in the control group (p=0.021). 25514356

2015

dbSNP: rs1468727
rs1468727
0.030 GeneticVariation BEFREE We identified two susceptibility tSNPs in the EGFR gene that were potentially associated with an increased risk of glioma (rs730437, p = 0.016; OR: 1.32; 95%CI: 1.05-1.66 and rs1468727, p = 0.008; OR: 1.31; 95%CI: 1.04-1.65). 22662167

2012

dbSNP: rs1468727
rs1468727
0.030 GeneticVariation BEFREE Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk. 23244079

2012

dbSNP: rs11506105
rs11506105
0.010 GeneticVariation BEFREE In addition, rs11506105 was significantly associated with an increased risk of glioma in both Asians and Caucasians, and rs11979158 decreased the risk of glioma in Caucasians. 29156842

2017

dbSNP: rs12718945
rs12718945
0.010 GeneticVariation BEFREE However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians. 29156842

2017

dbSNP: rs17172432
rs17172432
0.010 GeneticVariation BEFREE However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians. 29156842

2017

dbSNP: rs3752651
rs3752651
0.010 GeneticVariation BEFREE However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians. 29156842

2017

dbSNP: rs4947492
rs4947492
0.010 GeneticVariation BEFREE However, no significant association was observed between rs12718945/rs17172432/rs4947492 and glioma risk in Asians, between rs2252586 and glioma risk in Caucasians, and between rs3752651 and glioma risk in either Asians or Caucasians. 29156842

2017

dbSNP: rs845552
rs845552
0.010 GeneticVariation BEFREE The results showed a significant positive association between rs730437/rs845552 and glioma risk in Asians, and a significant negative association between them in Caucasians. 29156842

2017

dbSNP: rs397517132
rs397517132
0.010 GeneticVariation BEFREE We demonstrated that overexpression of PTPN9 reduces EGFR phosphorylation and cooperates with BRAF(V</span>600E</span>) in</span>hibitor PLX4720 to reduce MAPK and Akt signaling, resulting in decreased glioma cell viability. 26023796

2015