|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the mutation of rs1799782 significantly raises the risk of glioma for Asian.
|
26843108 |
2017 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Current evidence indicated that XRCC1 Arg194Trp polymorphism was associated with increased risk for glioma, especially in Asians; however, relevant studies involving other ethnic groups are required to validate our findings in further.
|
28423490 |
2017 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that glioma susceptibility is associated with rs1799782 and rs25487 of X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), rs1805377 of XRCC4, rs1800067 of excision repair cross-complementing rodent repair deficiency complementation group 4 (ERCC4) and rs3212986 of ERCC1 in Asian population, and rs12917 of O-6-methylguanine-DNA methyltransferase (MGMT) and rs1136410 of poly(ADP-ribose) polymerase 1 (PARP1) in Caucasian population.
|
27055523 |
2017 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma.
|
26843108 |
2017 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the dominant model, we found that the Arg/Trp + Trp/Trp genotype of XRCC1 Arg194Trp could significantly elevate the susceptibility of developing glioma (OR = 1.79, 95%CI = 1.07-0.94).
|
27706616 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we observed that the XRCC1 Arg399Gln genetic polymorphism did not influence the risk of glioma.
|
27706616 |
2016 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggested that the XRCC1 Arg194Trp polymorphism is a genetic risk factor for glioma, especially in Asian population.
|
25227852 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, rs1799782 increased the risk of glioma (OR = 1.89; 95%CI = 1.27-3.04), and a similar association was found for rs1800067 (OR = 1.89; 95%CI = 1.21-3.07).
|
24634177 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that XRCC1 Arg194Trp and Arg399Gln polymorphisms were associated with the risk of glioma.
|
24048757 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there may be no association between the Arg280His polymorphism and glioma risk, whereas the Arg399Gln/Arg194Trp polymorphisms may contribute to genetic susceptibility to glioma in the Chinese population.
|
25375625 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No evidence of significant associations between ERCC2 rs1799793, OGG1 rs1052133, XRCC1 rs25489, XRCC1 rs1799782, or XRCC3 rs861539 and risk of glioma was observed.
|
24500421 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194Trp polymorphism is associated with increased glioma risk among Asians, and Arg194Trp polymorphism is associated with decreased lung cancer risk among Caucasians.
|
25064613 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study demonstrates that the rs25489 (Arg280His) and Arg399Gln</span> (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.
|
25245010 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs25487 G/G genotype strongly and significantly increased the risk of glioma when compared with the rs25487 A/A genotype, indicated by an odds ratio (OR) = 2.23 [95% confidence interval (95%CI) = 1.36-3.87].
|
24634177 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there may be no association between the Arg280His polymorphism and glioma risk, whereas the Arg399Gln/Arg194Trp polymorphisms may contribute to genetic susceptibility to glioma in the Chinese population.
|
25375625 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the meta-analysis suggest a potential decreased susceptibility to glioma in association with the XRCC1 Arg39</span>9Gln polymorphism, especially in Asians.
|
24258108 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that XRCC1 Arg194Trp and Arg399Gln polymorphisms were associated with the risk of glioma.
|
24048757 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln, Arg194Trp, and Arg280His have drawn attention because of their potential associations with the development of glioma.
|
23712607 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the stratified analysis by ethnicity, the XRCC1 Arg399Gln</span> polymorphism had a higher risk of glioma development among Asians (for Gln vs Arg: OR = 1.34, 95 % CI 1.12-1.61; for GlnGln vs ArgArg: OR = 1.72, 95 % CI 1.18-2.51; for ArgGln vs ArgArg: OR = 1.31, 95 % CI 1.01-1.71; for GlnGln/ArgGln vs ArgArg: OR = 1.41, 95 % CI 1.10-1.80; for GlnGln vs ArgArg/ArgGln: OR = 1.48, 95 % CI 1.05-2.09)., but not among Caucasians.
|
23096083 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, our work also points out the importance of new studies for Arg399Gln association in some cancer types, such as glioma, gastric cancer, and oral cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg399Gln polymorphism in cancer development.
|
24205095 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk.
|
23244079 |
2012 |