Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE The rs6010620 (RTEL1), rs4977756 (CDKN2A/B), and rs498872 (PHLDB1) are associated with glioma risk in the Portuguese population and these data may contribute to understanding gliomas etiology. 31721021

2020

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25). 26243184

2016

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE This meta-analysis suggests that the RTEL1 rs6010620 polymorphism may be a risk factor for glioma. 25556444

2014

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma. 25227808

2014

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Overall, there was a significant association between RTEL1 rs6010620 polymorphism and glioma risk in all fo</span>ur genetic models (GG vs. AA: OR=1.87, 95 % CI=1.60-2.18, P heterogeneity=0.552; GA vs. AA: OR=1.30, 95 % CI=1.16-1.46, P heterogeneity=0.495; dominant model-GG+GA vs. AA: OR=1.46, 95 % CI=1.31-1.63, P heterogeneity=0.528; recessive model-GG vs. GA+AA: OR=1.36, 95 % CI=1.27-1.46, P heterogeneity=0.093). 24523019

2014

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Four of the five SNPs previously reported by others were statistically significantly associated with increased risk of glioma in our study (rs2736100, rs4295627, rs4977756, and rs6010620); rs498872 was not associated with glioma in our study. 23903690

2013

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03). 23161787

2013

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Two single variants, the genotypes of "GG" of rs</span>6010620 and "CC" of rs2297440 (rs6010620</span> and r</span>s2297440) in the RTEL1 gene, together with two haplotypes of GCT and ATT, were identified to be associated with glioma development. 23683922

2013

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE After Bonferroni correction for multiple comparisons, only one marker was statistically significantly associated with glioma risk, rs6010620 (ORtrend for the minor (A) allele, 0.39; 95% CI: 0.25-0.61; Bonferroni adjusted ptrend , 1.7 × 10(-4) ). 23115063

2013

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Genome-wide association studies have identified the susceptibility single nucleotide polymorphisms (SNPs) of glioma at chromosome 20q13.33, and the replication study conducted among Chinese Han population also confirmed the susceptibility locus rs6010620 is located in this region. 22387365

2012

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)). 21350045

2011

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population. 21920947

2011

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk. 20847058

2010

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk. 20462933

2010

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872). 20212223

2010

dbSNP: rs6010620
rs6010620
0.900 GeneticVariation BEFREE We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). 19578367

2009

dbSNP: rs2297440
rs2297440
0.820 GeneticVariation BEFREE This meta-analysis demonstrates that the RTEL1 rs2297440 polymorphism plays a moderate, but significant role in the risk of gli</span>oma. 26939676

2016

dbSNP: rs2297440
rs2297440
0.820 GeneticVariation BEFREE Two single variants, the genotypes of "GG" of rs6010620 and "CC" of rs2297440</span> (rs6010620 and rs2297440) in the RTEL1 gene, together with two haplotypes of GCT and ATT, were identified to be associated with glioma development. 23683922

2013

dbSNP: rs115303435
rs115303435
0.010 GeneticVariation BEFREE The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma</span> regardless of histological grades and molecular alterations. 30462709

2018

dbSNP: rs6062302
rs6062302
0.010 GeneticVariation BEFREE The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations. 30462709

2018