|
rs4849121
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
|
22197929 |
2011 |
|
rs6677604
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Moreover, rs6677604 might contribute to the difference of complement activation intensity between IgAVN and IgAN.
|
30838755 |
2020 |
|
rs6677604
|
|
|
0.750 |
GeneticVariation |
BEFREE |
We found both rs800292-GG and rs6677604-GG were risk genotypes for complement activation in IgAN patients, as represented by lower plasma C3 levels in IgAN patients with rs800292-GG and a higher intensity of glomerular C3 deposits in those with rs6677604-GG, respectively.
|
30219152 |
2018 |
|
rs6677604
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Our pooled analysis showed a significant association between rs6677604-(A) allele and Ig</span>AN susceptibility, supporting the importance of complement activation in the pathogenesis of IgAN.
|
29240274 |
2018 |
|
rs6677604
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The CFHR3,1Δ and rs6677604-A alleles were rare (4.4% in patients and 7.1% in controls) and in strong linkage disequilibrium with each other (r<sup>2</sup>=0.95); of these alleles, CFHR3,1Δ associated more significantly with decreased risk of IgAN (odds ratio [OR], 0.56; 95% confidence interval [95% CI], 0.46 to 0.70; P=8.5 × 10<sup>-8</sup> versus OR, 0.61; 95% CI, 0.50 to 0.75; P=1.6 × 10<sup>-6</sup> for rs6677604-A).
|
26940089 |
2016 |
|
rs6677604
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1-5, with rs6677604 in CFH as the top single-nucleotide polymorphism and CFHR3-1 deletion (CFHR3-1∆) as the top signal for copy number variation.
|
25205734 |
2015 |
|
rs6677604
|
|
G |
0.750 |
GeneticVariation |
GWASCAT |
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
|
25305756 |
2014 |
|
rs11264799
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Moreover, the haplotypes ACC (p = 0.02) and CTC (p = 0.017) of LD block rs11264794/rs7522061/rs11264799 in the FCRL3 gene were significantly associated with a decreased risk of IgAN.
|
31780315 |
2020 |
|
rs11264799
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We found that four SNPs (rs11264794, rs7865684, rs11264799, and rs6691569) were significantly associated with IgAN susceptibility after Bonferroni correction in the combined samples.
|
31433201 |
2019 |
|
rs9275596
|
|
|
0.720 |
GeneticVariation |
BEFREE |
After Cochran-Armitage test for trend analysis, seven IgAN-associated SNPs located in the major histocompatibility complex (MHC) region were found to be significantly associated with the susceptibility of IMN, with rs9275596 as the top one (p = 1.97E-43, OR = 3.977).
|
28929317 |
2017 |
|
rs9275596
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The T allele at rs9275596 was significantly associated with macroscopic haematuria of IgAN patients under the dominant and additive models of inheritance, (P < 0.001, Pc = 0.007, OR = 2.983) and (P < 0.001, Pc = 0.007, OR = 2.17), respectively.
|
27450519 |
2017 |
|
rs9275596
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A combination of the rs2856717T/C, rs9275596C/T, and rs2412971A/G had effects on the susceptibility of IgAN (P = 0.001).
|
27450519 |
2017 |
|
rs11264799
|
|
C |
0.720 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for IgA nephropathy in Han Chinese.
|
26028593 |
2015 |
|
rs9275596
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
|
25305756 |
2014 |
|
rs7190997
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We found that four SNPs (rs11150619, rs11150614, rs7190997, and rs4597342) showed potential associations with IgAN susceptibility in the discovery stage, but only SNP rs11150619 was further genotyped in the validation stage after multiple testing.
|
31227791 |
2019 |
|
rs17019602
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In comparison, neither rs4077515 nor rs17019602 showed significant association between genotype distribution and clinical parameters in IgAN patients (<i>P</i> > 0.05).
|
29100328 |
2017 |
|
rs2412971
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A combination of the rs2856717T/C, rs9275596C/T, and rs2412971A/G had effects on the susceptibility of IgAN (P = 0.001).
|
27450519 |
2017 |
|
rs2856717
|
|
|
0.710 |
GeneticVariation |
BEFREE |
A combination of the rs2856717T/C, rs9275596C/T, and rs2412971A/G had effects on the susceptibility of IgAN (P = 0.001).
|
27450519 |
2017 |
|
rs2856717
|
|
|
0.710 |
GeneticVariation |
BEFREE |
rs2856717 may influence the clinical characteristics and poor outcome of IgAN.
|
27450519 |
2017 |
|
rs4077515
|
|
|
0.710 |
GeneticVariation |
BEFREE |
For additive interaction, the CT or TT of rs</span>4077515 and GG of 17019602 genotype combination conferred a 2.56-fold risk of IgAN reference to CC of 4077515 and AA of 17019602 (OR = 2.56, 95% CI: 0.98-6.69, <i>P</i> = 0.049).
|
29100328 |
2017 |
|
rs12716641
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for IgA nephropathy in Han Chinese.
|
26028593 |
2015 |
|
rs2738058
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for IgA nephropathy in Han Chinese.
|
26028593 |
2015 |
|
rs7190997
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for IgA nephropathy in Han Chinese.
|
26028593 |
2015 |
|
rs12716641
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We found seven SNPs within DEFA genes that were significantly associated with IgAN, including rs2738048 discovered in our previous GWAS (p = 0.0007, OR = 0.77) and additional 6 SNPs (rs2615787, p = 0.0001, OR = 0.74; rs2738081, p = 0.0003, OR = 0.72; rs2738058, p = 0.0001, OR = 0.73; rs4288398, p = 0.0008, OR = 0.78; rs6984215, p = 0.002, OR = 0.63; rs12716641, p = 0.00002, OR = 0.71).
|
25024040 |
2014 |
|
rs17019602
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
|
25305756 |
2014 |