DisGeNET - a database of gene-disease associations

IGA Glomerulonephritis, C0017661

Variant: rs4961 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs4961

ADD1

0.030

GeneticVariation

BEFREE

The ADD1 G460W-dominant model for the G allele was significantly associated with hypertension of IgAN patients (P = 0.001, Pc = 0.031 and OR = 1.37).

24271554

2014

dbSNP:

rs4961

ADD1

0.030

GeneticVariation

BEFREE

In patients with IgA nephropathy, the rate of decline of renal function over time was associated to polymorphic beta-adducin (ADD2, 1797T, rs4984) with a significant interaction with alpha-adducin (ADD1, 460W, rs4961).

19838659

2010

dbSNP:

rs4961

ADD1

0.030

GeneticVariation

BEFREE

Therefore, we evaluated the clinical manifestations and renal prognosis in 276 Japanese patients with histologically proven IgA</span>N with respect to their ACE I/D and ADD1 G460W polymorphisms.

12885793

2003