|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
The rs4411444 GG genotype and G allele, the rs2300519 AA genotype, and the rs179247 AA genotype and A allele were more frequent in GD patients than they were in controls.
|
27762730 |
2017 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
SNPs rs179247 (dominant model [GG + GA vs. AA]: OR = 0.66, 95%CI: 0.61-0.73, P = 0.000, I(2) = 0%) and rs12101255 (dominant model [TT + TC vs. CC]: OR = 1.67, 95%CI: 1.53-1.83, P = 0.000, I(2) = 0%) were significantly associated with GD in all of the genetic models.
|
27456991 |
2016 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
A multivariate analysis showed that the inheritance of the thyroid-stimulating hormone receptor AA genotype for rs179247 increased the risk for Graves' disease (OR = 2.821; 95 % CI 1.595-4.990; p = 0.0004), whereas the thyroid-stimulating hormone receptor GG genotype for rs12885526 increased the risk for Graves' ophthalmopathy (OR = 2.940; 95 % CI 1.320-6.548; p = 0.0083).
|
25543543 |
2015 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Allele A of the rs179247 polymorphism in the TSHR gene is associated with lower risk of GO in young GD patients.
|
25061884 |
2014 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
The AT haplotype (rs1792</span>47-rs12101255) was associated with an increased risk of GD (P=0.010, OR=1.368).
|
22673349 |
2012 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies two new risk loci for Graves' disease.
|
21841780 |
2011 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Both rs179247 (P = 1.2×10(-2)-6.2×10(-15), OR = 1.38-1.45) and rs12101255 (P = 1.0×10(-4)-3.68×10(-21), OR = 1.47-1.87) exhibited strong association with GD in all three cohorts.
|
21124799 |
2010 |
|
rs179247
|
|
|
0.770 |
GeneticVariation |
BEFREE |
In total, 28 SNPs revealed association with GD (</span>P < 0.05), with strongest SNP associations at rs179247 (chi(2) = 32.45, P = 8.90 x 10(-8), OR = 1.53, 95% CI = 1.32-1.78) and rs12101255 (chi(2) = 30.91, P = 1.95 x 10(-7), OR = 1.55, 95% CI = 1.33-1.81), both located in intron 1 of the TSHR.
|
19244275 |
2009 |