Association analysis revealed both rs6832151 located in 4p14 (odds ratio (OR) = 1.27, P <sub>Allelic</sub> = 1.48 × 10<sup>-9</sup>) and rs9355610 located in 6q27 (OR = 1.10, P <sub>Allelic</sub> = 1.04 × 10<sup>-2</sup>) was associated with GD susceptibility.
However, genetic susceptibility is believed to play a major role.Recently, Chu et al. conducted a genome-wide association study in a Chinese Han population and identified two novel GD susceptibility loci within 4p14 (rs6832151) and 6q27 (rs9355610).