Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Association of congenital cardiac defects and the C677T methylenetetrahydrofolate reductase polymorphism. 17510921

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This article is to investigate the association between C677T polymorphism of 5, 10-methylenetetrahydrofolate (MTHFR) gene and congenital heart defects (CHD). 30334422

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Congenital heart defects (CHD) are the third leading cause of death in children <1 year of age in Mexico where there is a high prevalence of the 677C → T polymorphism of the MTHFR gene. 22660520

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Meta analysis of the association between MTHFR C677T polymorphism and the risk of congenital heart defects. 22175539

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Fifty percent of these isolated congenital cardiac defects were associated with either the C677T MTHFR mutation or elevated amniotic fluid homocysteine levels, or both. 11303187

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C gene polymorphisms are associated with the risk of patent ductus arteriosus (PDA) congenital heart defects. 24566197

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Evaluation of C677T and A1298C polymorphisms of the MTHFR gene as maternal risk factors for Down syndrome and congenital heart defects. 19725133

2009

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis. 24338416

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The MTHFR 677C->T polymorphism and the risk of congenital heart defects: a literature review and meta-analysis. 17965089

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism and risk of congenital heart defects: evidence from 29 case-control and TDT studies. 23536781

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE To observe the association of MTHFR gene C677T locus polymorphism with occurrence of congenital heart defects (CHDs), 21 patients with atrial septal defect (ASD), 35 patients with patent ductus arteriosus (PDA), one patient with both conditions combined, and their biological parents were collected as the case group. 16373366

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation. 16524890

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This study was undertaken to investigate the association between congenital heart defects (CHD), and maternal homocysteine, smoking, and the MTHFR 677 C>T polymorphism. 16389035

2006