|
rs10189761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF.
|
31209632 |
2019 |
|
rs10423928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs1136201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This review found that HER2 rs1136201 can have the potential in predicting trastuzumab-related heart failure.
|
30594345 |
2019 |
|
rs140226130
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included signs related to both ATTRm and ATTRwt such as chronic ischaemic heart disease (rs140226130, p = 2.00 × 10<sup>-6</sup>), heart failure (rs73956431, p = 2.74 × 10<sup>-6</sup>), atrial fibrillation (rs10163755, p = 4.63 × 10<sup>-6</sup>), dysphagia (rs2949506, p = 3.95 × 10<sup>-6</sup>), intestine diseases (rs970866, p = 7.14 × 10<sup>-6</sup>) and anxiety (rs554521234, p = 8.85 × 10<sup>-6</sup>).
|
31659433 |
2019 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034).
|
31275451 |
2019 |
|
rs1800437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs1801282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
|
31275366 |
2019 |
|
rs1805192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
|
31275366 |
2019 |
|
rs200432861
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The compound heterozygous variants c.7994T>C, p.(Leu2665Pro) and c.8518C>T, p.(Arg2840Cys) in PKHD1 were identified in a Chinese family with CHF by whole-exome sequencing.
|
30507656 |
2019 |
|
rs2230345
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity.
|
30978507 |
2019 |
|
rs3212247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, participants carrying the rs3212247 CC genotype had higher plasma levels of RIP3 than those carrying the TT or TC genotype (p for trend = 0.02) in New York Heart Association class III HF group.
|
31148336 |
2019 |
|
rs3212254
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was found between the RIP3 missense variant rs3212254 and risk or prognosis of HF after adjustment for traditional risk factors.
|
31148336 |
2019 |
|
rs4149056
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with OATP1B1 521T>C mutant-type carrier had slightly higher trough SDC (0.98 ± 0.53 ng/mL) than those with wild-type carrier (0.74 ± 0.40 ng/mL) when they have repaired renal function.Heart failure patients with severe renal dysfunction (GFR<60 mL/min) and/or OATP1B1 521T>C mutant-type carriers are recommended a smaller dosage of digoxin and strict therapeutic drug monitoring.
|
30946364 |
2019 |
|
rs548787835
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At 6 months of age when congestive heart failure is apparent in R120G mice, both LC3-II flux and TFEB activities were severely suppressed, while mTORC1 activity increased.
|
31297061 |
2019 |
|
rs7311358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Blood samples were collected for the analysis of trough SDC (immunofluorescence) and the polymorphisms of OATP1B1 388A>G, OATP1B1 521T>C, and OATP1B3 699G>A (PCR-RFLP and Sanger sequencing).Patients with glomerular filtration rate (GFR) under 30 mL/min had significantly higher trough SDC (1.20 ± 0.50 ng/mL) than recommended trough SDC for heart failure patients.
|
30946364 |
2019 |
|
rs737337
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF.
|
31209632 |
2019 |
|
rs73956431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included signs related to both ATTRm and ATTRwt such as chronic ischaemic heart disease (rs140226130, p = 2.00 × 10<sup>-6</sup>), heart failure (rs73956431, p = 2.74 × 10<sup>-6</sup>), atrial fibrillation (rs10163755, p = 4.63 × 10<sup>-6</sup>), dysphagia (rs2949506, p = 3.95 × 10<sup>-6</sup>), intestine diseases (rs970866, p = 7.14 × 10<sup>-6</sup>) and anxiety (rs554521234, p = 8.85 × 10<sup>-6</sup>).
|
31659433 |
2019 |
|
rs9303504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards models adjusted for established clinical risk factors and genomic ancestry tested the independent association of rs9909004 or rs9303504 and the variant interactions with cornerstone HF pharmacotherapies (beta-blockers or angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) in additive genetic models.
|
31728800 |
2019 |
|
rs9351814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs121918598
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Development of HF was not aggravated by increased SR Ca<sup>2+</sup> leak due to RyR2 mutation (R2474S) in volume overload, an SR Ca<sup>2+</sup> leak-independent HF model.
|
30209242 |
2018 |
|
rs1258130495
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This Arg16Gly genotype-dependent heterogeneity in clinical outcomes of HF was successfully validated in the second independent population.
|
30374408 |
2018 |
|
rs1544223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, the rs1544223 was significantly associated with CHF risk under the dominant model (<i>P</i> = 0.046, OR = 1.662, 95% CI = 1.009-2.738).But it did not affect disease severity.
|
29955603 |
2018 |
|
rs1805126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the rs1805126 minor allele associates with decreased cardiac SCN5A expression and that heart failure subjects homozygous for the minor allele have decreased ejection fraction and increased mortality, but not increased ventricular tachyarrhythmias.
|
29457789 |
2018 |
|
rs200536955
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that the human S10F mutant is associated with dysregulation of cell survival signalling, accelerated heart failure and early death post-partum.
|
29761889 |
2018 |
|
rs2241562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the presence of a minor allele at rs2241562 was associated with increased HF incidence in Chinese participants.
|
29191567 |
2018 |