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rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Since the pivotal role of β1 adrenergic receptor (β1-AR) in HF, many publications have studied the associations between the β1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results.
|
22815685 |
2012 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients.
|
21395649 |
2011 |
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rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression.
|
20803192 |
2010 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One study of risk for heart failure suggested a synergistic effect of ADRB1 Arg389Gly with the insertion/deletion polymorphism in the alpha2C-adrenergic receptor gene (ADRA2C).
|
17496726 |
2007 |
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rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure.
|
15735607 |
2005 |
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rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study.
|
12921807 |
2003 |
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rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Among individuals of African or Hispanic/Latino ancestry enrolled in 2 academic medical center-based biobanks, the TTR V122I genetic variant was significantly associated with heart failure.
|
31821430 |
2019 |
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rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This clinical algorithm may be useful for identification of ATTR V122I amyloidosis in elderly African American patients with HF.
|
28196196 |
2017 |
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rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Patients with ATTR V122I had the worst prognosis compared with other causes of Afro-Caribbean heart failure and white patients.
|
27618855 |
2016 |
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rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We did not detect a significant difference in mortality between V122I TTR allele carriers and noncarriers, a finding that contrasts with prior observations; however, the risk of heart failure was increased among carriers.
|
25551524 |
2015 |
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rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
It appears to be far less common than the previously described Val122Ile mutation but onset may be at an earlier age, potentially making heart transplantation a viable option should heart failure become severe.
|
23126592 |
2012 |
|
rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Transthyretin amyloidosis associated with variant V122I (ATTR V122I) is likely to be an important cause of heart failure in Afro-Caribbean populations, but the high prevalence of left ventricular hypertrophy (LVH) and lack of awareness of this genetic disorder pose diagnostic hurdles.
|
22795285 |
2012 |
|
rs76992529
|
|
|
0.070 |
GeneticVariation |
BEFREE |
After the age of 65 years (CHS), the frequencies of congestive heart failure (38% vs 15%, relative risk 2.62, P = .04) and mortality (76% vs 53%, relative risk 1.46, P = .08) were higher in V122I allele carriers than in age-, gender- and ethnically matched controls.
|
20435197 |
2010 |
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rs1801252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure.
|
30756358 |
2019 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Heart failure and endothelial nitric oxide synthase G894T gene polymorphism frequency variations within ancestries.
|
28554876 |
2018 |
|
rs1801252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Data from our study suggest that the β adrenoreceptor Gly 49 allele of the β1 -adrenergic receptor Ser(49) Gly polymorphisms may increase the risk of ICD shock in patients with heart failure, independent of beta-blocker dosage.
|
27027728 |
2016 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates.
|
25917853 |
2015 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease.
|
25612295 |
2015 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The current meta-analysis suggests that M235T polymorphism might be associated with increased risk of heart failure in Caucasians.
|
23154270 |
2014 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The pooled data showed that there was no significant associations between the AGT M235T polymorphism and HF</span> risk for TT vs. MM (OR = 1.17, 95%CI = 0.62-2.19, P = 0.635), MT vs. MM (OR = 0.97, 95%CI = 0.77-1.22, P = 0.776), MT/TT vs. MM (OR = 1.07, 95%CI = 0.67-1.69, P = 0.781), and TT vs. MM/MT (OR = 1.23, 95%CI = 0.86-1.76, P = 0.259).
|
24572548 |
2014 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
To evaluate the association between G894T GP and the prognosis of a sample of Brazilian outpatients with heart failure.
|
23949326 |
2013 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This prospective study was designed to analyze the impact of three eNOS polymorphisms (T-786C, VNTR4a/b and Glu298Asp) and their haplotypes on the susceptibility and clinical outcomes in HF outpatients with systolic dysfunction.
|
22290017 |
2012 |
|
rs1801252
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The Ser49Gly polymorphism did not impact the risk or prognosis of HF.
|
22815685 |
2012 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study.
|
20945963 |
2011 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase Glu298Asp gene polymorphism in a multi-ethnical population with heart failure and controls.
|
20079452 |
2010 |