Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure. 30756358

2019

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE The β1 adrenergic receptor (ADRB1) Arg389Gly, G-protein receptor kinase type 5 (GRK5) Gln41Leu, G-protein β-3 subunit (GNB3) 825 C/T, and α2c deletion affect adrenergic tone, impact heart failure outcomes and differ in prevalence by ethnicity. 30978507

2019

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1 Arg389Arg genotype). 29754666

2018

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE We used uniform methodology to investigate BB dose-ADRB1 Arg389Gly polymorphism interaction with major clinical end points in BEST/bucindolol and HF-ACTION/other BB databases. 30354340

2018

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE In conclusion, the β1 adrenergic receptor gene Arg389Gly polymorphism might not be associated with heart failure risk. 26125791

2015

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients. 23065660

2013

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE We examined whether the Arg389Gly polymorphism in ADRβ1 interacts with the dose requirements of beta-blockers in patients with systolic HF. 23115322

2013

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE The Arg389Gly polymorphism has a major impact on the heart-rate response to carvedilol (but not bisoprolol) in patients with heart failure plus atrial fibrillation. 22617224

2012

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE Since the pivotal role of β1 adrenergic receptor (β1-AR) in HF, many publications have studied the associations between the β1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results. 22815685

2012

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients. 21395649

2011

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression. 20803192

2010

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE One study of risk for heart failure suggested a synergistic effect of ADRB1 Arg389Gly with the insertion/deletion polymorphism in the alpha2C-adrenergic receptor gene (ADRA2C). 17496726

2007

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure. 15735607

2005

dbSNP: rs1801253
rs1801253
0.100 GeneticVariation BEFREE An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. 12921807

2003