Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913538
rs121913538
A 0.700 GeneticVariation CLINVAR Malignant transformation of infantile hemangioma to angiosarcoma: response to chemotherapy with bevacizumab. 24740626

2014

dbSNP: rs121913538
rs121913538
G 0.700 GeneticVariation CLINVAR Malignant transformation of infantile hemangioma to angiosarcoma: response to chemotherapy with bevacizumab. 24740626

2014

dbSNP: rs121913538
rs121913538
G 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs121913538
rs121913538
A 0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014

dbSNP: rs180177133
rs180177133
A 0.700 CausalMutation CLINVAR

dbSNP: rs121913529
rs121913529
0.010 GeneticVariation BEFREE Angiosarcoma showed a KRAS G12D point mutation, which is considered to be characteristic of vinyl chloride-induced angiosarcoma. 27544804

2016

dbSNP: rs1206992207
rs1206992207
0.010 GeneticVariation BEFREE The genetic bases of these tumors have been partially revealed in recent studies reporting genetic alterations such as amplifications of MYC (primarily in radiation-associated angiosarcomas), inactivating mutations in PTPRB and R707Q hotspot mutations of PLCG1. 26440310

2015

dbSNP: rs56302315
rs56302315
KDR
0.010 GeneticVariation BEFREE Likewise, activating mutations in the receptor tyrosine kinase KDR (VEGFR2) have been reported in angiosarcomas and non-small cell lung cancers; the KDR A1065T mutation is reported to be sensitive to VEGFR kinase inhibitors, and fibroblast growth factor receptor inhibitors are in trials. 25679062

2015

dbSNP: rs760881374
rs760881374
0.010 GeneticVariation BEFREE Together, these findings indicate that the PLCγ1-R707Q mutation causes constitutive activation of PLCγ1 and may represent an alternative way of activation of KDR/PLCγ1 signaling besides KDR activation in angiosarcomas, with implications for VEGF/KDR targeted therapies. 25252913

2014

dbSNP: rs1764391
rs1764391
0.010 GeneticVariation BEFREE A polymorphism in the human connexin37 (Cx37) gene (C1019T), resulting in a non-conservative amino acid change in the regulatory C-terminus (CT) of the Cx37 protein (P319S) has been suggested to be implicated in predisposition to angiosarcomas. 20705954

2010