rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Siderotic patients had the same geographic origin, serum and liver HCV RNA levels and H63D and C282Y mutations frequency as non-siderotic patients.
|
10568758 |
2000 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 2 known HFE mutations, cysteine 282 tyrosine (Cys282Tyr) and histidine 63 asparagine (His63Asp), were detected by polymerase chain reaction, and anti-HCV immunoglobulin G was detected serologically.
|
10688809 |
2000 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and severity of liver disease in hepatitis C virus (HCV) infection.
|
10692680 |
2000 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the frequency of C282Y and H63D mutations and HCV infection in Brazilian patients with PCT and their relationship with iron overload.
|
11151887 |
2000 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis.
|
14972004 |
2003 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Twenty-two patients (44%) were HCV-RNA positive; six out of them were heterozygous for H63D mutation, one only for the C282Y mutation and one was compound heterozygous for both mutations.
|
15101996 |
2004 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although statistically not significant, allele frequencies of H63D mutation in hepatitis B-related liver cirrhosis (6%) and hepatitis C-related liver cirrhosis (9.1%) were higher than those in healthy control (2%).
|
15780041 |
2005 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate analysis showed that C282Y heterozygous males were 3.8-fold (95% CI=1.0-15.2) more likely to be HBV positive and that H63D heterozygous females were 6.0-fold (95% CI=1.2-113.8) more likely to be HCV positive than wild type subjects.
|
15894495 |
2005 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relationship of H63D HFE gene mutations with chronic hepatitis C and the possible influence of HCV infection on iron metabolism needs further analysis.
|
16273299 |
2005 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The possibility of an association between HCV infection and H63D mutation in inducing PCT can be hypothesized.
|
17062032 |
2006 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes.
|
18565178 |
2008 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both C282Y and H63D were more frequent in PCT+ patients than in controls, but there was no difference in HFE genotype according to HCV seropositivity.
|
19001803 |
2009 |
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CONCLUSION THE: H63D mutation was an independent factor associated with SVR in chronic hepatitis C patients, as also were hepatitis C virus genotype 2 or 3 and transferrin saturation value of 45% or less.
|
20555268 |
2010 |