|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also studied their IL28B SNP (rs8099917) genotype, since a number of investigators have found a strong association of IL28B with spontaneous or treatment induced HCV clearance.
|
27511600 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of a Y93H variant was associated with higher HCV RNA levels and TT genotype at rs8099917 of IL28B.
|
25904097 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Then, the impact of the IFNL3 single nucleotide polymorphism genotype (TT/non-TT at rs8099917) on treatment outcomes was evaluated in the 180 patients, and between patients infected with either HCV sub-genotype 2a or 2b.
|
25852275 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B (rs12979860 and rs8099917) single nucleotide polymorphisms (SNPs) have been recently found among the Pakistani population associated with response to chronic HCV infection INF-α + ribavirin therapy.
|
26177560 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Spontaneous HCV clearance was significantly less common in the carriers of the rs8099917 allele G or rs12979860 allele T, while the CT rs12979860_rs8099917 haplotype was more frequent (P = 0.02) in patients showing spontaneous HCV clearance.
|
26658164 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Variants of the interleukin-28B (IL28B) gene correlate with an SVR to PR, and combined IL28B polymorphisms may improve the prediction of treatment outcome.The potential role of both rs8099917 and rs12979860 IL28B single nucleotide polymorphisms (SNPs) combined with presence of cryoglobulins in predicting SVR to PR in hepatitis C virus (HCV)-chronically infected patients was analyzed in the present study.Single and combined IL28B SNPs (rs12979860 and rs8099917) were analyzed in 64 chronic HCV patients treated with PR showing circulating cryoglobulins and compared to 108 noncryoglobulinemic subjects to verify the predictive value on the SVR.The association of rs12979860CC or rs8099917TT with SVR was confirmed in the noncryoglobulinemic group but not in cryoglobulinemic patients.
|
26334898 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study is to investigate whether this IL-28B SNP (rs8099917) and specific missense mutations in the HCV core region affect the response to IFN therapy for HCV genotype 3a.
|
25907669 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the distribution of HCV genotypes and single-nucleotide polymorphisms (SNPs) of IL28B (rs12979860 and rs8099917) in Pakistani population.
|
25703417 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In participants with HCV genotype 1, unfavorable genotypes for HCV clearance near IFNL3 were associated with increased HCC risk, the adjusted odds ratio (95% CI) for rs12979860 and rs8099917 being 1.73 (1.00-2.99) and 1.84 (1.02-3.33), respectively.
|
26602024 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Consequently, we suggest determining IL28B gene rs8099917 polymorphism of patients with HCV genotype 1 before onset of treatment.
|
25857516 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL13 rs20541 T allele and IL28B rs8099917 GG genotype are negative predictors of survival in patients on RRT, while the IL28B rs12979860 TT genotype increases the risk of death only in patients negative for HBV or HCV infection.
|
26039912 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This results demonstrate that in HCV genotype 4-infected patients, rs12979860 (CC) and rs8099917 (TT) genotypes may identify patients who are likely to respond to treatment.
|
25115611 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We describe the genotypes and allele distribution of interleukin 28B (IL28B) rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) in hepatitis C virus (HCV) G1-4 infected patients, to assess predictive ability and to determine whether the combined determination of two IL28B SNPs might improve sustained virologic response (SVR) prediction of both in HCV mono- and HIV/HCV co-infected patients.
|
26485009 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed at assessing the value of IL28B rs8099917 gene polymorphism in predicting sustained virological response (SVR) among HCV infected Egyptian patients treated with PEG-IFN and RBV.
|
26003758 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL-28B rs12979860 CC and rs8099917 TT genotypes were proved to be predictor for pegylated-interferon (PEG-IFN)/ribavirin (RBV)-treated hepatitis C virus (HCV) patients.
|
25769643 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of 126 participants with recent HCV infection from the Australian Trial in Acute Hepatitis C study demonstrated the prevalence of favorable single-nucleotide polymorphisms were 62%, 51%, and 45% for rs8099917 TT, rs12979860 CC, and rs368234815 TT/TT, respectively.
|
26150150 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we showed that IL-28 polymorphism rs8099917 strongly predicts virological response in HCV infection and that real-time PCR with Zip nucleic acid probes is a sensitive, specific and rapid detection method for detection of SNPs which will be essential for monitoring patients undergoing antiviral therapy.
|
25773845 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether the SNP of IL28B (rs8099917) and amino acid substitutions in the NS5A region in patients with HCV genotype 2 affect the response to IFN and ribavirin combination therapy.
|
24995561 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive.
|
25225180 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four paediatric studies have shown that both the CC genotype of the rs12979860 SNP and the TT genotype of the rs8099917 SNP are associated with the treatment-induced (IFN monotherapy and Pegylated-IFN-α and ribavirin association) clearance of HCV, while the rs12980275 SNP did not affect the virological response.
|
25071317 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the rs8099917 single-nucleotide polymorphism in 351 hepatitis C-associated HCC patients without history of IFN-based treatment, and correlated the age at onset of HCC in patients with each genotype.
|
23689989 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The goal of this study was to examine whether an IL28B polymorphism (rs8099917) is associated with natural clearance of HCV and with disease parameters of HCV infection in an HCV hyperendemic area of Japan.
|
25100136 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Impact of donor and recipient single nucleotide polymorphisms of IL28B rs8099917 in living donor liver transplantation for hepatitis C.
|
24599320 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did find that the four IL28B variants were in complete linkage disequilibrium (r(2) = 0.831-0.922), and the frequency of rs8099917 G</span>T genotype was significantly higher among chronic HCV-infected patients than among controls (OR = 2.21, 95% CI = 1.33-3.68, P = 0.00193); the G allele was found more frequently in the chronic HCV-infected group than in the control group (OR = 2.10, 95% CI = 1.28-3.44, P = 0.00276).
|
24144988 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A nationwide, multi-center prospective study in Japan determined IL28B (rs8099917) genotype, (TA)n of rs72258881, and amino acid substitutions of hepatitis C virus and used these for multivariate analysis together with other parameters at pretreatment.
|
24910341 |
2014 |