|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis indicated that cholesterol, triglyceride, low-density lipoprotein, 25-hydroxyvitamin D, platelets, duration of hemodialysis, HCV subtypes, IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ΔG/ΔG genotypes were associated with OCI.
|
30821879 |
2019 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition to rs4803217, also single nucleotide polymorphisms (SNPs) (rs12979860, rs8099917 and rs12980275) of known significance in predicting of HCV clearance were analyzed.
|
28638221 |
2017 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein were analyzed in 59 patients with HCC, and also in 50 cirrhotic patients (without HCC).
|
27035616 |
2016 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with rs10833 AA genotype had increased odds of having advanced fibrosis (adjusted odds ratio (aOR) = 2.30; P = 0.019), particularly in males (aOR = 2.24; P = 0.040), patients with HCV serum viral load (HCV-RNA) <500 000 IU/ml (aOR = 5.14; P = 0.018) and patients with IL28B rs12980275 AG/GG genotypes (aOR = 2.51; P = 0.046).
|
26836972 |
2016 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results showed the significant association of rs12980275</span> polymorphism with treatment response in HCV patients followed by rs12979860 and rs8099917.
|
25652367 |
2015 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B rs12980275 AA genotype is a strong predictor of positive response to IFN therapy in Chinese Han patients with hepatitis C.
|
25852288 |
2015 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
AA genotype of rs12980275 was a predictive factor for SVR in HCV patients with PEG-IFN/RBV treatment, especially in HCV genotype 1/4.
|
25769643 |
2015 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In hepatitis C virus genotype 1, the OR (95% CI) for rapid and sustained virological response for the wild-type ss469415590 TT was 9.88 (1.99-48.99) and 7.25 (1.91-27.51), respectively, similar to those found for rs12979860 CC [9.55 (1.93-47.37) and 6.30 (1.71-23.13)] and for rs12980275 AA [9.62 (1.94-47.77] and 7.83 (2.02-30.34)], but higher than for rs8099917 TT [4.8 (1.73-13.33) and 4.75 (2.05-10.98)].
|
24308755 |
2014 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that IL28B (rs12980275, rs11881222, rs12979860 and rs8099917) haplotype AACT had a protective effect for HCV infection (OR = 0.52, 95% CI = 0.33-0.83, P = 0.00551).
|
24144988 |
2014 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the work is to evaluate the predictive power of the rs12979860 IL28B SNP and rs12980275 IL28B SNP for treatment response in Egyptian patients infected with HCV genotype 4.
|
24999753 |
2014 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We characterized the IL28B genotype (for rs12980275 and rs8099917) in 308 patients (mean age, 56 y; 25% African American; 38% with advanced-stage fibrosis) with genotype 1 HCV infection seen at the Michael E. DeBakey Veterans Administration Medical Center in Houston, Texas, from May 1, 2009, through April 1, 2012.
|
23978349 |
2014 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Next, a decision tree showed early treatment failure increased from 37.1% to 65.5% when the unfavourable rs12980275 AG/GG and rs10903035 AG/GG genotypes and HCV-RNA≥ 500.000 IU/mL were taken into account in GT1/4 patients.
|
23565619 |
2013 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study attempted to demonstrate the role of single and combined IL28B polymorphisms (rs8099917, rs12979860 and rs12980275) and other host and viral factors in predicting response to treatment, in Caucasian patients infected with HCV genotype 1.
|
23831131 |
2013 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The major alleles of IL28B (rs12980275 A, rs11881222 A, rs8099917 T, and rs7248668 G) are associated with increased odds of liver disease severity in HIV patients infected with HCV-genotype 3.
|
23103287 |
2013 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown.
|
21112657 |
2011 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated predictive factors including HCV RNA, histological findings, IL28B SNP genotypes (rs8099917, rs12979860, and rs12980275), and the effect of treatment regimen and prior treatment history.
|
21112660 |
2011 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Independent predictors of SVR were rs12980275 AA (OR 9.68; 3.44-27.18), age <40 years (OR=4.79; 1.50-15.34) and HCV RNA <400 000 IU/mL (OR 2.74; 1.03-7.27) in HCV genotype 1 patients and rs12980275 AA (OR=6.26; 1.98-19.74) and age <40 years (OR 5.37; 1.54-18.75) in the 88 HCV genotype 1 patients without a RVR.
|
21443535 |
2011 |
|
rs12980275
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B SNPs rs8099917, rs12979860, and rs12980275 were genotyped in 242 HCV treatment-naïve Caucasian patients (67% genotype 1, 28% genotype 2 or 3) receiving peginterferon-α2a (180 μg weekly) and ribavirin (1000-1200 mg daily) with serial HCV-RNA quantifications.
|
21354446 |
2011 |