Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE CONCLUSION THE: H63D mutation was an independent factor associated with SVR in chronic hepatitis C patients, as also were hepatitis C virus genotype 2 or 3 and transferrin saturation value of 45% or less. 20555268

2010

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Both C282Y and H63D were more frequent in PCT+ patients than in controls, but there was no difference in HFE genotype according to HCV seropositivity. 19001803

2009

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE To determine the prevalence of the HFE gene mutations p.Cys282Tyr (C282Y), p.His63Asp (H63D) and p.Ser65Cys (S65C), the p.Tyr250X (Y250X) mutation of the TFR2 gene, and HCV infection in patients with PCT in the Czech population, and to make comparison of the iron status among the respective genotypes. 18565178

2008

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The possibility of an association between HCV infection and H63D mutation in inducing PCT can be hypothesized. 17062032

2006

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The relationship of H63D HFE gene mutations with chronic hepatitis C and the possible influence of HCV infection on iron metabolism needs further analysis. 16273299

2005

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Although statistically not significant, allele frequencies of H63D mutation in hepatitis B-related liver cirrhosis (6%) and hepatitis C-related liver cirrhosis (9.1%) were higher than those in healthy control (2%). 15780041

2005

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Multivariate analysis showed that C282Y heterozygous males were 3.8-fold (95% CI=1.0-15.2) more likely to be HBV positive and that H63D heterozygous females were 6.0-fold (95% CI=1.2-113.8) more likely to be HCV positive than wild type subjects. 15894495

2005

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Twenty-two patients (44%) were HCV-RNA positive; six out of them were heterozygous for H63D mutation, one only for the C282Y mutation and one was compound heterozygous for both mutations. 15101996

2004

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals. 12586300

2003

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis. 14972004

2003

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The aim of the present study was to investigate the frequency of C282Y and H63D mutations and HCV infection in Brazilian patients with PCT and their relationship with iron overload. 11151887

2000

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE Siderotic patients had the same geographic origin, serum and liver HCV RNA levels and H63D and C282Y mutations frequency as non-siderotic patients. 10568758

2000

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and severity of liver disease in hepatitis C virus (HCV) infection. 10692680

2000

dbSNP: rs1799945
rs1799945
0.100 GeneticVariation BEFREE The 2 known HFE mutations, cysteine 282 tyrosine (Cys282Tyr) and histidine 63 asparagine (His63Asp), were detected by polymerase chain reaction, and anti-HCV immunoglobulin G was detected serologically. 10688809

2000