|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sensitivity analyses suggested the robustness of the results in this meta-analysis.Both IL28B rs12979860 CC and rs8099917 TT genotypes are protective factors for the development of HCC among patients with HBV or HCV infection.
|
31568008 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of treatment response showed that CC (major) genotype of IFNL3 (rs12979860) and TT (major) genotype of IFNL3 (rs8099917) are associated with the likelihood of achieving a higher sustained virological response (SVR), to combined daclatasvir and sofosbuvir therapy, in genotype 3-infected HCV patients, whereas the individuals with TT (minor) genotype of IFNL3 (rs12979860) and GG (minor) genotype of IFNL3 (rs8099917) are more susceptible to chronic HCV infection and treatment relapse, suggesting a role of IFNL3 (rs12979860) and (rs8099917) in the treatment outcome of combined daclatasvir and sofosbuvir therapy in chronic HCV genotype 3 infection.
|
30431653 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most significant positive factors affecting the SC HCV included IL-28B single nucleotide polymorphism (SNP) rs12979860 (CC) and SNP rs8099917 (TT) (OR 4.03, p<0.001) and (OR 3.14, p<0.002), female gender (OR 2.72, p<0.001), young age (OR 2.30, p<0.008), and past history of jaundice (OR 5.12, p<0.001).
|
31060998 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL28B rs8099917 genotypes were determined among 100 HCV-infected patients and the viral load was also estimated.
|
30988680 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Host DNA from all HCV positive patients and age- and sex-matched non-HCV-infected control individuals were analysed for IL28B single nucleotide polymorphism (SNP) (rs12979860 and rs8099917).
|
30865664 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis indicated that cholesterol, triglyceride, low-density lipoprotein, 25-hydroxyvitamin D, platelets, duration of hemodialysis, HCV subtypes, IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ΔG/ΔG genotypes were associated with OCI.
|
30821879 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of IL-28B in Asian patients with different viral genotypes remains elusive.We try to elucidate the effect of IL-28B genetic variants in a large Asian cohort with different viral genotypes.The association between the IL-28B rs8099917 genotype and liver fibrosis was investigated in 1288 patients with biopsy-proven CHC.Patients with hepatitis C virus genotype 1 (HCV-1) infection comprised 59.4% of the population.
|
29517696 |
2018 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B (rs8099917 and rs12979860) and IL10 (rs1800896) polymorphisms alone, or in combination, are good predictors of therapeutic response in HCV-3a patients.
|
29340806 |
2018 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients.
|
29499724 |
2018 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
High frequencies of a favorable IL-28B rs8099917 polymorphism and the clinical implications in patients with HCV in one multiracial area of Taiwan.
|
28962822 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of interleukin-28B rs12979860 and rs8099917 polymorphisms with sustained viral response in hepatitis C virus genotype 1 and 3 infected patients from the Indian subcontinent.
|
27514956 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition to rs4803217, also single nucleotide polymorphisms (SNPs) (rs12979860, rs8099917 and rs12980275) of known significance in predicting of HCV clearance were analyzed.
|
28638221 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease.
|
28513591 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multiple logistic regression analysis found female gender, IL28B rs8099917 TT genotype, HBV co-infection and blood donors (vs drug users) associated with increased spontaneous clearance of HCV infection.
|
27943542 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings indicate that serum IFNL3 levels at baseline are higher in AHC patients regardless of the rs8099917 polymorphism, and primary HCV infection triggers the production of IFNL3.
|
29040985 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 101 Japanese patients who had underwent liver biopsy before treatment with pegIFN and ribavirin for HCV genotype 1b infection were retrospectively analyzed for association between <i>IFNL3</i> genotypes (rs8099917) and clinical factors including histopathological features of the liver.
|
29104462 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 557 HCV-seroreactive individuals with thalassemia were processed for HCV viral genotyping and host IL28B single-nucleotide polymorphism analysis at loci rs12979860 and rs8099917.
|
28419488 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, higher glucose levels were found in T2D patients carrying the IL28B CT/TT rs12979860 and GT/GG rs8099917 HCV risk genotypes compared to those with the protective CC and TT genotype (p=0.06 and p=0.02, respectively).
|
27664841 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In adjusted analyses, low plasma maxi-LVP level was independently associated with spontaneous HCV clearance (≤827 IU/ml; adjusted odds ratio 3.98, 95% CI: 1.02, 15.51, P = 0.047), after adjusting for interferon lambda-3 rs8099917 genotype, estimated duration of HCV infection and total HCV RNA level.
|
27224844 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
the Interferon lambda (IFNL) polymorphisms genotypes (rs8099917, rs12979860 and rs12980275) and the presence of mutations in HCV core protein were analyzed in 59 patients with HCC, and also in 50 cirrhotic patients (without HCC).
|
27035616 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To analyze the genetic heterogeneity of the Amerindian and admixed population (Mestizos) based on the IL28B (rs12979860, rs8099917) and IFNL4 (rs368234815) haplotypes, and their association with spontaneous clearance (SC) and liver damage in patients with hepatitis C infection from West Mexico.
|
26741362 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the association of IL28B rs8099917 genotype with baseline data, including HCV RNA level, HCV genotype, histological activity grade, fibrosis stage, and body mass index, were evaluated and further stratified by covariant factors.
|
27751759 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of IL28B SNPs rs12979860 and rs8099917 on Hepatitis C Virus-RNA Status in Donors/Recipients of Living Donor Liver Transplantation.
|
27275739 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population.
|
26660164 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Favourable genotypes of IFNL3 polymorphism CC for rs12979860 and TT for rs8099917 are strongly associated with the interferon/ribavirin treatment outcome in hepatitis C virus (HCV) patients with genotypes 1 and 4.
|
27498543 |
2016 |