|
rs10196867
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.
|
31462767 |
2019 |
|
rs147247472
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.
|
31462767 |
2019 |
|
rs2133896
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence.
|
31462767 |
2019 |
|
rs2288156
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Association of Heroin Dependence in Han Chinese.
|
27936112 |
2016 |
|
rs4791746
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Association of Heroin Dependence in Han Chinese.
|
27936112 |
2016 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A recent study suggested that a second nearby variant within OPRM1, rs3778150, is robustly associated with heroin dependence and fully explained a smaller observed association with rs1799971.
|
28273335 |
2017 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The haplotype structure of rs3778150 and nearby SNPs may underlie the inconsistent associations between rs1799971 and heroin addiction.
|
25744370 |
2015 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The present pilot study characterized the impact of OPRM1 genotype (rs1799971, 118G allele carriers vs. 118AA homozygotes) on heroin-use phenotypes associated with heroin dependence severity in a sample of male, Caucasian chronic heroin users (n = 86).
|
25911999 |
2015 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
On the other hand, significant association was observed for A118G with heroin addiction (χ²=7.268, P=0.0264) as well as with alcoholic addition (χ²=6.626, P=0.0364).
|
22138325 |
2012 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.
|
21277709 |
2011 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
For the A118G polymorphism, we found significant differences in allele and genotype frequencies between different ethnic groups and highly significant association with heroin dependence in Indians for both genotype distribution (p = 0.024) and allele frequency (p = 0.009).
|
12657887 |
2003 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This study suggests that the variant G allele of both A118G and C1031G polymorphisms may contribute to the vulnerability to heroin dependence.
|
11338173 |
2001 |
|
rs1800497
|
|
|
0.040 |
GeneticVariation |
BEFREE |
According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2/ANKK1 polymorphisms (rs1800497, rs1800498, rs1079597 and rs4648319); this was most notable in the late-onset HD subgroup.
|
28854834 |
2019 |
|
rs1800497
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We also conducted a meta-analysis of the association between a widely studied variant, rs1800497, and heroin dependence as a representative example and obtained a consistent outcome with our results.
|
29550268 |
2018 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Additionally, we found that rs6265, rs11030104 and rs10767664 in BDNF were associated with a decreased risk of heroin addiction (p < 0.05).
|
27647760 |
2016 |
|
rs1800497
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In single marker analysis the TaqIA (rs1800497) and TaqIB (rs1079597) variants were associated with heroin dependence.
|
23840506 |
2013 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, the rs6265 polymorphism may be a risk factor for methamphetamine dependence in south Asian subjects or for heroin dependence in Chinese subjects.
|
24279859 |
2013 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings suggested that the BDNF genetic polymorphism (rs6265) may have effects on the age of onset of heroin dependence among the Chinese population.
|
22856871 |
2012 |
|
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These findings support a role of BDNF rs6265 and rs13306221 polymorphisms in heroin dependence and may guide future studies to identify other genetic risk factors for heroin dependence.
|
21458533 |
2011 |
|
rs1800497
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate the potential association of dopamine receptor D2 gene (DRD2) TaqI RFLP A (rs1800497) and dopamine transporter gene (DAT) 3'untranslated region VNTR genetic variations with heroin addiction.
|
19664686 |
2009 |
|
rs1079597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
According to the allele, genotype and haplotype frequency analysis, we observed an association between HD and several DRD2/ANKK1 polymorphisms (rs1800497, rs1800498, rs1079597 and rs4648319); this was most notable in the late-onset HD subgroup.
|
28854834 |
2019 |
|
rs2234918
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotype distribution and allelic frequency analyses showed that the minor C allele of rs2234918 in OPRD1 is over-represented in the HD group (P = .006 and P = .002, respectively).
|
30171993 |
2019 |
|
rs2236857
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Gene-stress assessment in the HD group showed that T/T homozygotes of OPRD1 rs2236857 have more severe stress than C allele carriers (Ns, P = .004 and Na, P = .047).
|
30171993 |
2019 |
|
rs3778150
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent study suggested that a second nearby variant within OPRM1, rs3778150, is robustly associated with heroin dependence and fully explained a smaller observed association with rs1799971.
|
28273335 |
2017 |
|
rs3778150
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The haplotype structure of rs3778150 and nearby SNPs may underlie the inconsistent associations between rs1799971 and heroin addiction.
|
25744370 |
2015 |