SNP interaction was cross-examined by logistic regression and multifactor dimensionality reduction analysis revealing that <i>VAMP5</i> rs1254900 and <i>MCC</i> rs11241200 were interacting significantly, thereby contributing to the risk of HSCR.
Our recent genome-wide association study has identified a variant (rs1254900) of vesicle-associated membrane protein 5 (VAMP5) as a potential risk locus for total colonic aganglionosis (TCA) in HSCR.