DisGeNET - a database of gene-disease associations

Hyperglycemia, C0020456

Gene: GCK ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs764232985

GCK

0.700

GeneticVariation

CLINVAR

Mutations in GCK and HNF-1alpha explain the majority of cases with clinical diagnosis of MODY in Spain.

17573900

2007

dbSNP:

rs1064793998

GCK

0.720

CausalMutation

CLINVAR

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

18399931

2008

dbSNP:

rs1057524903

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

18399931

2008

dbSNP:

rs1085307455

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.

18399931

2008

dbSNP:

rs1085307455

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).

18411240

2008

dbSNP:

rs1085307455

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.

18382660

2008

dbSNP:

rs1562715574

GCK ; LOC105375258

0.700

GeneticVariation

CLINVAR

Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.

18382660

2008

dbSNP:

rs1064793998

GCK

0.720

CausalMutation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs1064793998

GCK

0.720

GeneticVariation

BEFREE

The glucokinase V62M and G72R mutations are naturally occurring and known to associate with hyperglycemia in humans.

19187021

2009

dbSNP:

rs1064793998

GCK

0.720

CausalMutation

CLINVAR

The glucokinase V62M and G72R mutations are naturally occurring and known to associate with hyperglycemia in humans.

19187021

2009

dbSNP:

rs1057524901

GCK

0.700

GeneticVariation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs1057524901

GCK

0.700

GeneticVariation

CLINVAR

Novel mutations in GCK and HNF1A genes in Italian families with MODY phenotype.

19150152

2009

dbSNP:

rs1057524902

GCK

0.700

CausalMutation

CLINVAR

Human Splicing Finder: an online bioinformatics tool to predict splicing signals.

19339519

2009

dbSNP:

rs1057524902

GCK

0.700

CausalMutation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs1057524904

GCK ; LOC105375258

0.700

GeneticVariation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs1057524904

GCK ; LOC105375258

0.700

GeneticVariation

CLINVAR

Maturity-onset diabetes of the young in children with incidental hyperglycemia: a multicenter Italian study of 172 families.

19564454

2009

dbSNP:

rs1057524905

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Human Splicing Finder: an online bioinformatics tool to predict splicing signals.

19339519

2009

dbSNP:

rs1057524905

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs1057524906

GCK

0.700

GeneticVariation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs1085307455

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.

19309449

2009

dbSNP:

rs1085307455

GCK ; LOC105375258

0.700

CausalMutation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs556581174

GCK

0.700

CausalMutation

CLINVAR

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.

19790256

2009

dbSNP:

rs764232985

GCK

0.700

GeneticVariation

CLINVAR

Glucokinase gene mutation screening in Argentinean clinically characterized MODY patients.

19358091

2009

dbSNP:

rs193922289

GCK

0.010

GeneticVariation

BEFREE

The glucokinase V62M and G72R mutations are naturally occurring and known to associate with hyperglycemia in humans.

19187021

2009

dbSNP:

rs1057524900

GCK

0.700

GeneticVariation

CLINVAR

Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.

20337973

2010