|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In studies conducted in several different populations, the M235T substitution in the angiotensinogen (AGT) locus has been associated with hypertension.
|
9034402 |
1997 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension.
|
9170002 |
1997 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The formerly described, but controversial, association of the M235T polymorphism with arterial hypertension could not be confirmed in this study.
|
9950302 |
1999 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension.
|
10608470 |
1999 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There are inconsistent reports that the angiotensinogen (ATG) variant Met235-->Thr (T235) allele and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) variants are associated with hypertension and related target organ damage.
|
10487325 |
1999 |
|
rs568401628
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results are consistent with the thesis that the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated more often with the condition of high blood pressure than with normal blood pressure.
|
10100091 |
1999 |
|
rs142677199
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of the A640G gene variation with the presence and extent of CAD was not only identified in the total sample, but was even stronger in various high risk subpopulations of younger individuals (e.g. with hypertension with or without increased apolipoprotein B plasma levels).
|
10488959 |
1999 |
|
rs761401927
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of the A640G gene variation with the presence and extent of CAD was not only identified in the total sample, but was even stronger in various high risk subpopulations of younger individuals (e.g. with hypertension with or without increased apolipoprotein B plasma levels).
|
10488959 |
1999 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The M235T polymorphism of the angiotensinogen gene may be associated with a higher risk of hypertension.
|
11134677 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of AGT has been studied extensively in many populations including Japanese, and the results suggest a weak, but significant linkage with hypertension.
|
11128865 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension.
|
10862638 |
2000 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One DNA polymorphism within exon 2- with threonine instead of methionine at position 235 (M235T) was found to be significantly associated with hypertension.
|
12169209 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension.
|
14610337 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease.
|
12911327 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ThrThr genotype of the angiotensinogen (AGT) Met235Thr polymorphism has been associated with elevated AGT levels, hypertension, increased heart disease risk, and improved blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitors.
|
14643574 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect.
|
15386947 |
2004 |
|
rs568401628
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the beta3-adrenergic receptor gene may favor the central adiposity gain.
|
14739355 |
2004 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ACE I/D polymorphism does not contribute to the presence and severity of essential hypertension, while the AGT M235T TT genotype confers a significantly decreased risk for the development of hypertension in the population studied here.
|
15642127 |
2005 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
People who carried both ACE ID (or DD) and AGT M235T MT (or MM) had more risk to have hypertension.
|
16685579 |
2006 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, no association was found between M235T polymorphism and insulin resistance or PAI-1 levels, but results indicate relationship between I/D polymorphism of the ACE gene and plasma PAI-1 levels in the early stage of hypertension.
|
16981142 |
2006 |
|
rs1415088003
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The aim of the study was to verify the hypothesis if the interaction between the G protein beta3 subunit (GNB3) C825T polymorphism and ACE I/D polymorphism could lead to the disclosure of increased activity of sodium-proton exchanger and hypertension.
|
16314202 |
2006 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |