Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE In studies conducted in several different populations, the M235T substitution in the angiotensinogen (AGT) locus has been associated with hypertension. 9034402

1997

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy. 9049480

1997

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE To examine whether the angiotensinogen M235T and angiotensin converting enzyme insertion/deletion (I/D) variants are related to the severity of hypertension in patients with established essential hypertension. 9170002

1997

dbSNP: rs1415088003
rs1415088003
ACE
0.020 GeneticVariation BEFREE Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension. 26821322

2016

dbSNP: rs4305
rs4305
ACE
0.020 GeneticVariation BEFREE The MDR analysis demonstrated that the interaction between BMI and rs4305 increased the susceptibility to hypertension. 24015270

2013

dbSNP: rs4305
rs4305
ACE
0.020 GeneticVariation BEFREE A polymorphism in ACE (rs4305) showed modest replication of association with increased hypertension (β: 0.06 mm Hg; SE: 0.01 mm Hg; meta-analysis: P=3.0×10(-5)). 21444836

2011

dbSNP: rs1415088003
rs1415088003
ACE
0.020 GeneticVariation BEFREE The aim of the study was to verify the hypothesis if the interaction between the G protein beta3 subunit (GNB3) C825T polymorphism and ACE I/D polymorphism could lead to the disclosure of increased activity of sodium-proton exchanger and hypertension. 16314202

2006

dbSNP: rs568401628
rs568401628
ACE
0.020 GeneticVariation BEFREE In adolescents of European origin, hypertension is associated with an increased degree of obesity among other characteristics of the metabolic syndrome; the Trp64Arg variant of the beta3-adrenergic receptor gene may favor the central adiposity gain. 14739355

2004

dbSNP: rs568401628
rs568401628
ACE
0.020 GeneticVariation BEFREE Our results are consistent with the thesis that the Trp64Arg polymorphism of the beta 3-adrenergic receptor gene is associated more often with the condition of high blood pressure than with normal blood pressure. 10100091

1999

dbSNP: rs1799752
rs1799752
ACE
0.010 GeneticVariation BEFREE We did not observe associations between hypertension and rs1799752 (<i>P</i>=0.422), rs699 (<i>P</i>=0.36), rs5186 (<i>P</i>=0.49), and rs1799998 (<i>P</i>=0.71). 31511791

2019

dbSNP: rs4362
rs4362
ACE
0.010 GeneticVariation BEFREE When the cohort was stratified by sex, ACE rs4362 and AGT rs699 showed significant associations with WMLs in men only (P = 0.01 and P = 0.03, respectively), and remained significant after controlling for hypertension. 24622918

2014

dbSNP: rs4363
rs4363
ACE
0.010 GeneticVariation BEFREE Under a dominant model, rs4291 rs4335, rs4344, rs4353, rs4362, and rs4363 polymorphisms were associated with an increased risk of hypertension after adjusting for age, gender, BMI, triglycerides, alcohol consumption, and smoking. 23741507

2013

dbSNP: rs4291
rs4291
ACE
0.010 GeneticVariation BEFREE Four polymorphisms, located in the ACE (rs4291), angiotensinogen (rs5049) and (pro)renin receptor (rs2968915; rs5981008) genes were significantly associated with hypertension in two vascular disease populations of CAD (EUROPA) and cerebrovascular disease (PROGRESS; n = 3571). 21157371

2011

dbSNP: rs1156835126
rs1156835126
ACE
0.010 GeneticVariation BEFREE We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. 21053180

2010

dbSNP: rs553520266
rs553520266
ACE
0.010 GeneticVariation BEFREE We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. 21053180

2010

dbSNP: rs746566272
rs746566272
ACE
0.010 GeneticVariation BEFREE We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. 21053180

2010

dbSNP: rs755506668
rs755506668
ACE
0.010 GeneticVariation BEFREE We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília. 21053180

2010

dbSNP: rs1042309696
rs1042309696
ACE
0.010 GeneticVariation BEFREE Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension. 18212314

2008

dbSNP: rs142677199
rs142677199
ACE
0.010 GeneticVariation BEFREE The association of the A640G gene variation with the presence and extent of CAD was not only identified in the total sample, but was even stronger in various high risk subpopulations of younger individuals (e.g. with hypertension with or without increased apolipoprotein B plasma levels). 10488959

1999

dbSNP: rs761401927
rs761401927
ACE
0.010 GeneticVariation BEFREE The association of the A640G gene variation with the presence and extent of CAD was not only identified in the total sample, but was even stronger in various high risk subpopulations of younger individuals (e.g. with hypertension with or without increased apolipoprotein B plasma levels). 10488959

1999