|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, meta-regression analysis indicated that the effect of the Glu298Asp genotype on the risk of hypertension might be dependent on total cholesterol status.
|
17762636 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension.
|
17594145 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology.
|
17563560 |
2007 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 35 genetic association studies that examined the relation between hypertension and the G894T, 4a/b, T786C, and G23T polymorphisms of the endothelial nitric oxide synthase gene was carried out.
|
16940230 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Intron 4 B/B genotype was significantly associated with the hypertension group (P = 0.035), but disequilibrium of G894T and T-786C was absent between the two groups (P = 0.419 and P = 0.227), respectively.
|
17024134 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results do not support the hypothesis that the E298D polymorphism contributes to the genetic susceptibility to hypertension.
|
15942458 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the associations between the nitric oxide synthase gene (NOS3) Glu298Asp polymorphism and hypertension status or blood pressure (BP) levels have had inconsistent results.
|
15505116 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggested no association between the Glu298Asp gene polymorphism and the incidence of hypertension in this selected population.
|
15475025 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, a missense Glu298Asp mutation in exon 7 of the eNOS gene is reported to be a risk factor for hypertension or myocardial infarction.
|
12701818 |
2003 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-based cohort of hypertensive and control subjects.
|
11905585 |
2002 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension.
|
11710784 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We recently identified a missense variant (Glu298Asp) that lies within exon 7 of the endothelial nitric oxide synthase (eNOS) gene, and that is associated with severe preeclampsia (proteinuric hypertension that develops as a consequence of pregnancy).
|
11354626 |
2001 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the Glu298Asp variant may be a genetic susceptibility factor for hypertension.
|
10883733 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multiple logistic regression revealed that the most predictive independent risk factor for coronary spasm was the T-786-->C mutation (P < 0.001), followed by cigarette smoking (P < 0.001), hypertension (P = 0.004), and the Glu298Asp variant (P = 0.028).
|
10979242 |
2000 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The relevance of the Glu298Asp polymorphism to hypertension in this population was tested in 2 ways.
|
10205226 |
1999 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We recently identified rs3918226 as a hypertension susceptibility locus (-665 C>T), TT homozygosity being associated with higher hypertension risk.
|
25102225 |
2015 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
For hypertension associations were seen for additional SNPs including NOS3 SNP rs3918226, previously associated with hypertension in genome-wide association study (GWAS) data.
|
24713495 |
2014 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, rs3918226 in the eNOS promoter tags a hypertension susceptibility locus, TT homozygosity being associated with lesser transcription and higher risk of hypertension.
|
24019403 |
2013 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636).
|
23122309 |
2012 |
|
rs3918226
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial NO synthase gene (odds ratio: 1.54 [95% CI: 1.37-1.73]; combined P=2.58 · 10(-13)).
|
22184326 |
2012 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We therefore aimed to meta-analyze three eNOS widely-evaluated polymorphisms, G894T (rs1799983) in exon 7, 4b/a in intron 4, and T-786C (rs2070744) in promoter region, in association with hypertension from both English and Chinese publications, while addressing between-study heterogeneity and publication bias.
|
21912683 |
2011 |
|
rs2070744
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs7830
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, no study has tested the hypothesis that NOS3 tagSNPs rs3918226, rs3918188, rs743506 and rs7830 affect nitrite levels and are associated with hypertension in childhood obesity.
|
24943287 |
2015 |