Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The allele frequency of AGT M235T differed significantly between group 1 (patients with simple renal cysts and hypertension) and normal individuals (p < 0.05). 23907112

2015

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Gene polymorphisms of adducin GLY460TRP, ACE I/D, AND AGT M235T in pediatric hypertension patients. 25262176

2014

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension. 23598646

2013

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Renin-angiotensin-aldosterone system (RAAS) polymorphisms such as the angiotensinogen-gene-M235T-, the angiotensin-conversion enzyme (ACE)-gene I/D- and the angiotensin-II-type 1-receptor-(AT1R)-A1166C-polymorphism have been implicated in renal insufficiency and hypertension. 19681973

2010

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy. 18413162

2008

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE We studied the effects of the angiotensinogen T174M and M235T, angiotensin converting enzyme insertion/deletion (ACE I/D), and angiotensin II receptor 1 (AT1R) A1166C gene polymorphisms on the risk of hypertension among Hispanics. 18497458

2008

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE We also screened angiotensinogen gene AGT M235T and angiotensin-converting enzyme insertion/deletion polymorphism ACE I/D and found an association between TT genotype and hypertension. 18758497

2008

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians. 17448297

2007

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE In Slovak population, M235T is associated with increased blood pressure and D allele of ACE gene is associated with MI, chronic CHD and DCM, rather than with hypertension. 17579251

2007

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE People who carried both ACE ID (or DD) and AGT M235T MT (or MM) had more risk to have hypertension. 16685579

2006

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension. 16876684

2006

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE In conclusion, no association was found between M235T polymorphism and insulin resistance or PAI-1 levels, but results indicate relationship between I/D polymorphism of the ACE gene and plasma PAI-1 levels in the early stage of hypertension. 16981142

2006

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The ACE I/D polymorphism does not contribute to the presence and severity of essential hypertension, while the AGT M235T TT genotype confers a significantly decreased risk for the development of hypertension in the population studied here. 15642127

2005

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE Haplotype frequencies for M235T and G-6A were significantly different between hypertensive individuals and controls, which indicated an association of angiotensinogen gene haplotypes with hypertension, and a significant association of 235T/-6A haplotype with hypotensive effect. 15386947

2004

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE One DNA polymorphism within exon 2- with threonine instead of methionine at position 235 (M235T) was found to be significantly associated with hypertension. 12169209

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. 12911327

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population. 12938141

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The ACE-I/D polymorphism was shown to be a risk factor of progression of renal disease and the AGT-M235T polymorphism was associated with the severity of arterial hypertension. 14610337

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The ThrThr genotype of the angiotensinogen (AGT) Met235Thr polymorphism has been associated with elevated AGT levels, hypertension, increased heart disease risk, and improved blood pressure (BP) response to angiotensin-converting enzyme (ACE) inhibitors. 14643574

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE In a Dutch IDDM population, including 69 patients with (incipient) diabetic nephropathy, the T-allele of the AGT-M235T polymorphism is associated with an elevated UAE and diabetic retinopathy and the CC-genotype of the AT1-A1166C polymorphism is associated with hypertension. 10862638

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE M235T polymorphism of AGT has been studied extensively in many populations including Japanese, and the results suggest a weak, but significant linkage with hypertension. 11128865

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The M235T polymorphism of the angiotensinogen gene may be associated with a higher risk of hypertension. 11134677

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE There are inconsistent reports that the angiotensinogen (ATG) variant Met235-->Thr (T235) allele and angiotensin-converting enzyme (ACE) insertion/deletion (I/D) variants are associated with hypertension and related target organ damage. 10487325

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE No association was observed between the M235T variant or 3'-microsatellite polymorphism of the AGT gene and hypertension. 10608470

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.100 GeneticVariation BEFREE The formerly described, but controversial, association of the M235T polymorphism with arterial hypertension could not be confirmed in this study. 9950302

1999