|
rs1057518965
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1336343565
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555119899
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555257073
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1555908409
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs3218716
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs74315329
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Intrabone marrow transplantation into immunodeficient mice further showed that MA4 and KRAS(G12V) alone or in combination enhanced hematopoietic repopulation without impairing myeloid-lymphoid differentiation, and that mutated KRAS did not cooperate with MA4 to initiate leukemia.
|
26837759 |
2016 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Here we present the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene (KRAS(G12D)), to produce serially transplantable, polyclonal, invasive ductal carcinomas within 8 weeks of being introduced either subrenally or subcutaneously into immunodeficient mice.
|
26633636 |
2015 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs1131691021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In contrast, the combination of p53 RNAi knockdown with expression of oncogenic H-Ras(G12V) transformed the p16-deficient BAR-T cells, as evidenced by their loss of contact inhibition, by their formation of colonies in soft agar, and by their generation of tumors in immunodeficient mice.
|
20927195 |
2010 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In contrast, the combination of p53 RNAi knockdown with expression of oncogenic H-Ras(G12V) transformed the p16-deficient BAR-T cells, as evidenced by their loss of contact inhibition, by their formation of colonies in soft agar, and by their generation of tumors in immunodeficient mice.
|
20927195 |
2010 |
|
rs1131691021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs1015164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple genome-wide studies have identified associations between outcome of human immunodeficiency virus (HIV) infection and polymorphisms in and around the gene encoding the HIV co-receptor CCR5, but the functional basis for the strongest of these associations, rs1015164A/G, is unknown.
|
31209403 |
2019 |
|
rs2204985
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strikingly, transplantation of human hematopoietic stem cells with the rs2204985 GG genotype into immunodeficient mice led to thymopoiesis with higher TRECs, increased thymocyte counts, and a higher TCR repertoire diversity.
|
30185651 |
2018 |
|
rs28931594
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we revealed that the expressions of IL15, CCL5, IL1A, IL23R and TLR5 are down-regulated in keratinocytes expressing Cx26-D50N, suggesting that immune deficiency in KID syndrome expressing Cx26-D50N might be associated not only with skin barrier defects, but also with the down-regulated expression of immune response-related genes.
|
30150638 |
2018 |
|
rs8177832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that the distribution of rs8177832 genotypes AA, AG and GG in healthy subjects and HIV-1 subjects was; 42.253%, 42.957%, 14.788% and 66%, 27%, 7% respectively.
|
30338740 |
2018 |
|
rs1188975135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we show that the S61P mutation in human A3C (A3C.S61P) boosted hypermutation in the viral genomes of simian immunodeficiency virus Δvif and murine leukemia virus but not in human immunodeficiency virus HIV-1Δvif.
|
28315663 |
2017 |
|
rs28399499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We characterized the HIV-1-infected children (n = 60) for the CYP2B6 c.516G>T, c.785A>G, c.983T>C, and c.1459C>T single nucleotide polymorphisms (SNPs).
|
28816644 |
2017 |
|
rs3211371
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We characterized the HIV-1-infected children (n = 60) for the CYP2B6 c.516G>T, c.785A>G, c.983T>C, and c.1459C>T single nucleotide polymorphisms (SNPs).
|
28816644 |
2017 |
|
rs352140
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the TLR9 rs352140 AA variant genotype was associated with susceptibility to HIV+/HCV+ co-infection in African descendants (recessive, OR=2.92; 95% CI: 1.22-6.98, P=0.016).
|
28062211 |
2017 |
|
rs3745274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We characterized the HIV-1-infected children (n = 60) for the CYP2B6 c.516G>T, c.785A>G, c.983T>C, and c.1459C>T single nucleotide polymorphisms (SNPs).
|
28816644 |
2017 |
|
rs2227513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2227513 A/G genotype was also associated with significantly higher levels of plasma IL-22, regardless of whether the patient was HIV seropositive or seronegative.
|
25556046 |
2016 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression of exogenous copies of AKT1(E17K) in MCF10A breast epithelial cells increased phosphorylation of AKT and its substrates, induced colony formation in soft agar, and formation of lesions in the mammary fat pad of immunodeficient mice.
|
26351323 |
2015 |