The results suggested that rs2477686, rs6080550, and rs10842262 were significantly associated with male infertility</span>, especially with NOA, while rs12097821 was only found to be associated with total male infertility.
A previous genomewide association study of nonobstructive azoospermia (NOA) in the Han Chinese population identified three risk loci (rs12097821, rs2477686, and rs10842262) and provided strong evidence for a genetic influence in male infertility.