Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Sensitivity analyses indicated that the final consequences of this meta-analysis were stable, and the publication biases test had not found obvious asymmetry.This meta-analysis indicates that MTHFR C677T, A1298C, and MTRR A66G polymorphisms are the risk factors with susceptibility to male infertility in Asians. 30813130

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase gene (MTHFR C677T and A1298C) and methionine synthase gene (MS A2756G) polymorphisms have shown an association with male infertility risk in several ethnic populations. 28081209

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE This meta-analysis suggests that MTHFR C677T polymorphism is associated with male infertility. 28363185

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The presence of MTHFR C677T, contributing at most for male infertility, was determined from a venous blood sample, using real-time polymerase chain reaction (PCR). 28842818

2017

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, the current meta-analysis showed that the MTHFR C677T polymorphism was associated with a significantly increased male infertility risk in the Asian and overall populations, but not in the Caucasian population, and there was a significant association between the A1298C polymorphism and male infertility risk in the Asian, Caucasian, and overall groups. 27173242

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Based on our results, we suggest that C677T transition in MTHFR may increase the risk of male infertility, and detection of the C677T polymorphism biomarker may be helpful in the screening of idiopathic male infertility. 25412139

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis is in favor that the MTHFR C677T polymorphism is capable of causing male infertility susceptibility, especially in Asians and the subgroup of azoospermia. 26584688

2016

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. 25578539

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Overall, MTHFR 677C>T polymorphism showed significant associations with male infertility risk in both fixed effects (CT+TT vs. CC: OR = 1.34, 95% CI: 1.23-1.46) and random effects models (CT+TT vs. CC: OR = 1.39, 95% CI: 1.19-1.62). 25793386

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population. 26549413

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population. 25966116

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, this study showed that MTHFR C677T polymorphism is associated with male infertility in Jordanians. 24334125

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The homozygous MTHFR C677T genotype was a risk factor for male infertility</span> during 5-year follow-up, whereas a correlation between MTHFR A1298C and infertility was not observed. 24737513

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We found an association of C677T polymorphism with male infertility and that it may be a genetic risk factor for male infertility in North Indian population. 24366618

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The overall results of the study indicate that MTHFR C677T polymorphism is not associated with male infertility. 21729137

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene has been suggested to represent a risk factor for male infertility. 22928696

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis supports that MTHFR C677T polymorphism is capable of causing male infertility susceptibility in Asians, but not in Caucasians. 21535009

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Overall, we found that both 677C>T and 1298A>C polymorphisms were not significantly associated with male infertility risk. 21643754

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE 677C>T substitution associated strongly with male infertility in Indian population. 21799811

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism is associated with an increased risk of idiopathic male infertility. 20978181

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility. 21138341

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our findings indicate that there is an association of SNP C677T in the MTHFR gene with male infertility, suggesting that this polymorphism might be a genetic risk factor for male infertility in Chinese men. 16888682

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR C677T polymorphism, GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction? 16484136

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE By analysis of a large number of subjects and a more specific patient selection, we showed the first genetic evidence that MTHFR C677T, MS A2756G and MTRR A66G genotypes were independently associated with male infertility. 16861746

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE To determine whether 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) genotype is associated with male infertility. 16247718

2005