rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sensitivity analyses indicated that the final consequences of this meta-analysis were stable, and the publication biases test had not found obvious asymmetry.This meta-analysis indicates that MTHFR C677T, A1298C, and MTRR A66G polymorphisms are the risk factors with susceptibility to male infertility in Asians.
|
30813130 |
2019 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase gene (MTHFR C677T and A1298C) and methionine synthase gene (MS A2756G) polymorphisms have shown an association with male infertility risk in several ethnic populations.
|
28081209 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that MTHFR C677T polymorphism is associated with male infertility.
|
28363185 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of MTHFR C677T, contributing at most for male infertility, was determined from a venous blood sample, using real-time polymerase chain reaction (PCR).
|
28842818 |
2017 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the current meta-analysis showed that the MTHFR C677T polymorphism was associated with a significantly increased male infertility risk in the Asian and overall populations, but not in the Caucasian population, and there was a significant association between the A1298C polymorphism and male infertility risk in the Asian, Caucasian, and overall groups.
|
27173242 |
2016 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Based on our results, we suggest that C677T transition in MTHFR may increase the risk of male infertility, and detection of the C677T polymorphism biomarker may be helpful in the screening of idiopathic male infertility.
|
25412139 |
2016 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis is in favor that the MTHFR C677T polymorphism is capable of causing male infertility susceptibility, especially in Asians and the subgroup of azoospermia.
|
26584688 |
2016 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility.
|
25578539 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, MTHFR 677C>T polymorphism showed significant associations with male infertility risk in both fixed effects (CT+TT vs. CC: OR = 1.34, 95% CI: 1.23-1.46) and random effects models (CT+TT vs. CC: OR = 1.39, 95% CI: 1.19-1.62).
|
25793386 |
2015 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population.
|
26549413 |
2015 |
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population.
|
25966116 |
2015 |
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this study showed that MTHFR C677T polymorphism is associated with male infertility in Jordanians.
|
24334125 |
2014 |
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The homozygous MTHFR C677T genotype was a risk factor for male infertility</span> during 5-year follow-up, whereas a correlation between MTHFR A1298C and infertility was not observed.
|
24737513 |
2014 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found an association of C677T polymorphism with male infertility and that it may be a genetic risk factor for male infertility in North Indian population.
|
24366618 |
2014 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The overall results of the study indicate that MTHFR C677T polymorphism is not associated with male infertility.
|
21729137 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene has been suggested to represent a risk factor for male infertility.
|
22928696 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis supports that MTHFR C677T polymorphism is capable of causing male infertility susceptibility in Asians, but not in Caucasians.
|
21535009 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, we found that both 677C>T and 1298A>C polymorphisms were not significantly associated with male infertility risk.
|
21643754 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
677C>T substitution associated strongly with male infertility in Indian population.
|
21799811 |
2011 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism is associated with an increased risk of idiopathic male infertility.
|
20978181 |
2011 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this study was to analyze the distribution of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in idiopathic infertile Brazilian patients with nonobstructive azoospermia (NOA) or severe oligozoospermia and fertile Brazilian men as controls to explore the possible association of these polymorphisms and male infertility.
|
21138341 |
2011 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that there is an association of SNP C677T in the MTHFR gene with male infertility, suggesting that this polymorphism might be a genetic risk factor for male infertility in Chinese men.
|
16888682 |
2007 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism, GSTM1 deletion and male infertility: a possible suggestion of a gene-gene interaction?
|
16484136 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By analysis of a large number of subjects and a more specific patient selection, we showed the first genetic evidence that MTHFR C677T, MS A2756G and MTRR A66G genotypes were independently associated with male infertility.
|
16861746 |
2006 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine whether 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) genotype is associated with male infertility.
|
16247718 |
2005 |