Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10841496
rs10841496
PDE3A
0.800 GeneticVariation GWASDB Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs10841496
rs10841496
PDE3A
0.800 GeneticVariation GWASCAT Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs1399645
rs1399645
LOC105373644
0.800 GeneticVariation GWASDB Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs1399645
rs1399645
LOC105373644
0.800 GeneticVariation GWASCAT Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs6068020
rs6068020 		0.800 GeneticVariation GWASDB Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs6068020
rs6068020 		0.800 GeneticVariation GWASCAT Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs9814870
rs9814870 		0.800 GeneticVariation GWASCAT Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs9814870
rs9814870 		0.800 GeneticVariation GWASDB Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. 19478329

2010
dbSNP: rs374623109
rs374623109
FSHB ; LOC105376607
T 0.700 GeneticVariation CLINVAR Novel FSHβ mutation in a male patient with isolated FSH deficiency and infertility. 28392474

2017
dbSNP: rs1555979575
rs1555979575
CLDN2 ; MORC4
C 0.700 CausalMutation CLINVAR

dbSNP: rs1569167515
rs1569167515
POLR2F ; SOX10
G 0.700 CausalMutation CLINVAR

dbSNP: rs200750564
rs200750564
HOXD13
T 0.700 CausalMutation CLINVAR

dbSNP: rs864309485
rs864309485
TEX15
C 0.700 CausalMutation CLINVAR

dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Sensitivity analyses indicated that the final consequences of this meta-analysis were stable, and the publication biases test had not found obvious asymmetry.This meta-analysis indicates that MTHFR C677T, A1298C, and MTRR A66G polymorphisms are the risk factors with susceptibility to male infertility in Asians. 30813130

2019
dbSNP: rs397507444
rs397507444
MTHFR
0.100 GeneticVariation BEFREE Sensitivity analyses indicated that the final consequences of this meta-analysis were stable, and the publication biases test had not found obvious asymmetry.This meta-analysis indicates that MTHFR C677T, A1298C, and MTRR A66G polymorphisms are the risk factors with susceptibility to male infertility in Asians. 30813130

2019
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase gene (MTHFR C677T and A1298C) and methionine synthase gene (MS A2756G) polymorphisms have shown an association with male infertility risk in several ethnic populations. 28081209

2017
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE This meta-analysis suggests that MTHFR C677T polymorphism is associated with male infertility. 28363185

2017
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE The presence of MTHFR C677T, contributing at most for male infertility, was determined from a venous blood sample, using real-time polymerase chain reaction (PCR). 28842818

2017
dbSNP: rs397507444
rs397507444
MTHFR
0.100 GeneticVariation BEFREE This study suggests that the MTHFR C667T polymorphism may contribute to the genetic susceptibility to male infertility in the Chinese population, whereas MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility. 28081209

2017
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE In conclusion, the current meta-analysis showed that the MTHFR C677T polymorphism was associated with a significantly increased male infertility risk in the Asian and overall populations, but not in the Caucasian population, and there was a significant association between the A1298C polymorphism and male infertility risk in the Asian, Caucasian, and overall groups. 27173242

2016
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Based on our results, we suggest that C677T transition in MTHFR may increase the risk of male infertility, and detection of the C677T polymorphism biomarker may be helpful in the screening of idiopathic male infertility. 25412139

2016
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis is in favor that the MTHFR C677T polymorphism is capable of causing male infertility susceptibility, especially in Asians and the subgroup of azoospermia. 26584688

2016
dbSNP: rs397507444
rs397507444
MTHFR
0.100 GeneticVariation BEFREE In conclusion, the current meta-analysis showed that the MTHFR C677T polymorphism was associated with a significantly increased male infertility risk in the Asian and overall populations, but not in the Caucasian population, and there was a significant association between the A1298C polymorphism and male infertility risk in the Asian, Caucasian, and overall groups. 27173242

2016
dbSNP: rs397507444
rs397507444
MTHFR
0.100 GeneticVariation BEFREE There was no association found between the A1298C variant and male infertility. 25412139

2016
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. 25578539

2015