rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations.
|
30987701 |
2019 |
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs763362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076).
|
31114873 |
2019 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes.
|
29202190 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For each sample <i>IFITM3</i> rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point.
|
29868492 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here strong association between rs12252 and influenza was found in all four genetic models.
|
30421689 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicated increased risk of both severe and mild influenza in subjects carrying the IFITM3 rs12252 polymorphism in the allele contrast C vs. T: OR (severe) = 1.69, 95% CI = 1.23-2.33, P = 0.001, and OR (mild) = 1.46, 95% CI = 1.13-1.87, P = 0.004.
|
29940276 |
2018 |
rs8072510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b><i>IFITM3</i> rs12252</span> CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection.
|
28713779 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial.
|
28714988 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity.
|
28531322 |
2017 |
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant difference among healthy pregnant R620W carriers and non-carriers in H1N1 antibody seroconversion rates after influenza vaccination.
|
28723925 |
2017 |
rs34481144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity.
|
28714988 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection.
|
27351739 |
2016 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza.
|
27492307 |
2016 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
|
25778715 |
2015 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher homozygous frequency in patients with severe acute influenza.
|
25784441 |
2015 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza</span> susceptibility, but not in mild influenza subjects, in both UK Caucasians and Han Chinese population.
|
25942469 |
2015 |
rs1048479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
rs113350588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.
|
23997235 |
2014 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
They also suggested that mechanisms, other than viral entry restriction, might contribute to variations in clinical outcomes of H1N1 influenza associated with rs12252-C.
|
25314048 |
2014 |
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we demonstrate that the presence of the IL-28B TG/GG genotype (rs8099917, minor-allele) was associated with increased seroconversion following influenza vaccination (OR 1.99 p = 0.038).
|
25503988 |
2014 |