|
rs1801274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional single nucleotide polymorphism rs1801274 in the FCGR2A gene (His131Arg) influences the efficiency of hIgG2 binding, the main isotype produced in response to encapsulated bacteria like Streptococcus pneumoniae and Haemophilus influenzae.
|
16893392 |
2006 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038).
|
21159925 |
2011 |
|
rs773340854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038).
|
21159925 |
2011 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro.
|
22446628 |
2012 |
|
rs2229291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recent studies suggested that the thermolabile phenotype of carnitine palmitoyltransferase II (CPT II) variation [F352C] was closely related to the pathomechanism of influenza-associated encephalopathy (IAE) in Japanese, causing mitochondrial ATP utilization failure during periods of high fever, resulting in brain edema.
|
21277129 |
2012 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
|
23361009 |
2013 |
|
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00).
|
24282567 |
2013 |
|
rs1468575151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a novel mutation, N84S in the PB1F2 protein of 9·35% of the highly pathogenic avian influenza H5N1 influenza viruses.
|
22788742 |
2013 |
|
rs7744020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in the Human Leukocyte Antigen (HLA)- DQ region were associated with age of onset (rs7744020 P = 7.9×10(-9) beta -1.9 years) and varied significantly among cases with onset after the 2009 H1N1 influenza pandemic compared to previous years (rs9271117 P = 7.8 × 10(-10) OR 0.57).
|
24204295 |
2013 |
|
rs9271117
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in the Human Leukocyte Antigen (HLA)- DQ region were associated with age of onset (rs7744020 P = 7.9×10(-9) beta -1.9 years) and varied significantly among cases with onset after the 2009 H1N1 influenza pandemic compared to previous years (rs9271117 P = 7.8 × 10(-10) OR 0.57).
|
24204295 |
2013 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection.
|
23997235 |
2014 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
They also suggested that mechanisms, other than viral entry restriction, might contribute to variations in clinical outcomes of H1N1 influenza associated with rs12252-C.
|
25314048 |
2014 |
|
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we demonstrate that the presence of the IL-28B TG/GG genotype (rs8099917, minor-allele) was associated with increased seroconversion following influenza vaccination (OR 1.99 p = 0.038).
|
25503988 |
2014 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
|
25778715 |
2015 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher homozygous frequency in patients with severe acute influenza.
|
25784441 |
2015 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza</span> susceptibility, but not in mild influenza subjects, in both UK Caucasians and Han Chinese population.
|
25942469 |
2015 |
|
rs1048479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
|
rs113350588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection.
|
27351739 |
2016 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza.
|
27492307 |
2016 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b><i>IFITM3</i> rs12252</span> CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection.
|
28713779 |
2017 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial.
|
28714988 |
2017 |
|
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity.
|
28531322 |
2017 |
|
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant difference among healthy pregnant R620W carriers and non-carriers in H1N1 antibody seroconversion rates after influenza vaccination.
|
28723925 |
2017 |
|
rs34481144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity.
|
28714988 |
2017 |