rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs763362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076).
|
31114873 |
2019 |
rs8072510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant difference among healthy pregnant R620W carriers and non-carriers in H1N1 antibody seroconversion rates after influenza vaccination.
|
28723925 |
2017 |
rs34481144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found evidence of a new association of rs34481144 with severe influenza in three influenza-infected cohorts characterized by different levels of influenza illness severity.
|
28714988 |
2017 |
rs1048479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
rs113350588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we demonstrate that the presence of the IL-28B TG/GG genotype (rs8099917, minor-allele) was associated with increased seroconversion following influenza vaccination (OR 1.99 p = 0.038).
|
25503988 |
2014 |
rs1468575151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a novel mutation, N84S in the PB1F2 protein of 9·35% of the highly pathogenic avian influenza H5N1 influenza viruses.
|
22788742 |
2013 |
rs7744020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in the Human Leukocyte Antigen (HLA)- DQ region were associated with age of onset (rs7744020 P = 7.9×10(-9) beta -1.9 years) and varied significantly among cases with onset after the 2009 H1N1 influenza pandemic compared to previous years (rs9271117 P = 7.8 × 10(-10) OR 0.57).
|
24204295 |
2013 |
rs9271117
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in the Human Leukocyte Antigen (HLA)- DQ region were associated with age of onset (rs7744020 P = 7.9×10(-9) beta -1.9 years) and varied significantly among cases with onset after the 2009 H1N1 influenza pandemic compared to previous years (rs9271117 P = 7.8 × 10(-10) OR 0.57).
|
24204295 |
2013 |
rs2229291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recent studies suggested that the thermolabile phenotype of carnitine palmitoyltransferase II (CPT II) variation [F352C] was closely related to the pathomechanism of influenza-associated encephalopathy (IAE) in Japanese, causing mitochondrial ATP utilization failure during periods of high fever, resulting in brain edema.
|
21277129 |
2012 |
rs773340854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038).
|
21159925 |
2011 |
rs1801274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional single nucleotide polymorphism rs1801274 in the FCGR2A gene (His131Arg) influences the efficiency of hIgG2 binding, the main isotype produced in response to encapsulated bacteria like Streptococcus pneumoniae and Haemophilus influenzae.
|
16893392 |
2006 |
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00).
|
24282567 |
2013 |
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038).
|
21159925 |
2011 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations.
|
30987701 |
2019 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes.
|
29202190 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For each sample <i>IFITM3</i> rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point.
|
29868492 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here strong association between rs12252 and influenza was found in all four genetic models.
|
30421689 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicated increased risk of both severe and mild influenza in subjects carrying the IFITM3 rs12252 polymorphism in the allele contrast C vs. T: OR (severe) = 1.69, 95% CI = 1.23-2.33, P = 0.001, and OR (mild) = 1.46, 95% CI = 1.13-1.87, P = 0.004.
|
29940276 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b><i>IFITM3</i> rs12252</span> CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection.
|
28713779 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial.
|
28714988 |
2017 |