rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b><i>IFITM3</i> rs12252</span> CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection.
|
28713779 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity.
|
28531322 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes.
|
29202190 |
2018 |
rs763362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076).
|
31114873 |
2019 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For each sample <i>IFITM3</i> rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point.
|
29868492 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here strong association between rs12252 and influenza was found in all four genetic models.
|
30421689 |
2018 |
rs8099917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we demonstrate that the presence of the IL-28B TG/GG genotype (rs8099917, minor-allele) was associated with increased seroconversion following influenza vaccination (OR 1.99 p = 0.038).
|
25503988 |
2014 |
rs113350588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
rs1048479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a second phase of the study, the rs113350588 and rs1048479 polymorphisms identified in this sample were genotyped in a sample of 356 subjects from the northern and northeastern regions of Brazil with a diagnosis of pandemic influenza.
|
26436774 |
2015 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations.
|
30987701 |
2019 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals.
|
23361009 |
2013 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs8072510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs4986791
|
|
|
0.020 |
GeneticVariation |
BEFREE |
On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038).
|
21159925 |
2011 |
rs773340854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038).
|
21159925 |
2011 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza</span> susceptibility, but not in mild influenza subjects, in both UK Caucasians and Han Chinese population.
|
25942469 |
2015 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
|
25778715 |
2015 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicated increased risk of both severe and mild influenza in subjects carrying the IFITM3 rs12252 polymorphism in the allele contrast C vs. T: OR (severe) = 1.69, 95% CI = 1.23-2.33, P = 0.001, and OR (mild) = 1.46, 95% CI = 1.13-1.87, P = 0.004.
|
29940276 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial.
|
28714988 |
2017 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection.
|
27351739 |
2016 |
rs2229291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recent studies suggested that the thermolabile phenotype of carnitine palmitoyltransferase II (CPT II) variation [F352C] was closely related to the pathomechanism of influenza-associated encephalopathy (IAE) in Japanese, causing mitochondrial ATP utilization failure during periods of high fever, resulting in brain edema.
|
21277129 |
2012 |
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs1801274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The functional single nucleotide polymorphism rs1801274 in the FCGR2A gene (His131Arg) influences the efficiency of hIgG2 binding, the main isotype produced in response to encapsulated bacteria like Streptococcus pneumoniae and Haemophilus influenzae.
|
16893392 |
2006 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza.
|
27492307 |
2016 |