rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes.
|
29202190 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
For each sample <i>IFITM3</i> rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point.
|
29868492 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here strong association between rs12252 and influenza was found in all four genetic models.
|
30421689 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicated increased risk of both severe and mild influenza in subjects carrying the IFITM3 rs12252 polymorphism in the allele contrast C vs. T: OR (severe) = 1.69, 95% CI = 1.23-2.33, P = 0.001, and OR (mild) = 1.46, 95% CI = 1.13-1.87, P = 0.004.
|
29940276 |
2018 |
rs8072510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza.
|
29053189 |
2018 |
rs12252
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations.
|
30987701 |
2019 |
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05).
|
31196204 |
2019 |
rs763362
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076).
|
31114873 |
2019 |