Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. 30987701

2019

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (>99%) across all rs12252 genotypes. 29202190

2018

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE For each sample <i>IFITM3</i> rs12252 genotype was determined and antibody levels in response to pdmH1N1, H3N2 and Influenza B infection were measured for each time point. 29868492

2018

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza. 29053189

2018

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Here strong association between rs12252 and influenza was found in all four genetic models. 30421689

2018

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Our results indicated increased risk of both severe and mild influenza in subjects carrying the IFITM3 rs12252 polymorphism in the allele contrast C vs. T: OR (severe) = 1.69, 95% CI = 1.23-2.33, P = 0.001, and OR (mild) = 1.46, 95% CI = 1.13-1.87, P = 0.004. 29940276

2018

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE <b>Conclusion:</b><i>IFITM3</i> rs12252</span> CC genotype was associated with severity rather than susceptibility of IVI in Chinese population, and this strong effect was observed in all subtypes of seasonal influenza infection. 28713779

2017

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Previous studies have reported associations of IFITM3 SNP rs12252 with severe influenza, but evidence of association and the mechanism by which risk is conferred remain controversial. 28714988

2017

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE rs12252 was not associated with susceptibility to influenza-related critical illness in children or with critical illness severity. 28531322

2017

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Recent studies suggest an association between the Interferon Inducible Transmembrane 3 (IFITM3) rs12252 variant and the course of influenza infection. 27351739

2016

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE The only Spanish patient homozygous for rs12252-C had a neurological disorder (a known risk factor for severe IVI) and mild influenza. 27492307

2016

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection. 25778715

2015

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher homozygous frequency in patients with severe acute influenza. 25784441

2015

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Our meta-analysis suggests a significant association between a minor IFITM3 allele (SNP rs12252-C) with severe influenza</span> susceptibility, but not in mild influenza subjects, in both UK Caucasians and Han Chinese population. 25942469

2015

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection. 23997235

2014

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE They also suggested that mechanisms, other than viral entry restriction, might contribute to variations in clinical outcomes of H1N1 influenza associated with rs12252-C. 25314048

2014

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. 23361009

2013

dbSNP: rs12252
rs12252
0.100 GeneticVariation BEFREE We find that a statistically significant number of hospitalized subjects show enrichment for a minor IFITM3 allele (SNP rs12252-C) that alters a splice acceptor site, and functional assays show the minor CC genotype IFITM3 has reduced influenza virus restriction in vitro. 22446628

2012

dbSNP: rs4986791
rs4986791
0.020 GeneticVariation BEFREE TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). 24282567

2013

dbSNP: rs4986791
rs4986791
0.020 GeneticVariation BEFREE On the contrary, the presence of the TLR4-T399I polymorphism was associated with a 2-fold decreased risk of Haemophilus influenzae carriage (OR = 0.38, 95% CI = 0.15 to 0.96, P = 0.038). 21159925

2011

dbSNP: rs16944
rs16944
0.010 GeneticVariation BEFREE The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05). 31196204

2019

dbSNP: rs2275913
rs2275913
0.010 GeneticVariation BEFREE The frequencies of the IL-1β rs16944 (P = 0.007) and IL-17 rs2275913 (P = 0.006) genotypes were associated with severe influenza disease, while the frequencies of IL-10 rs1800872 and IL-28 rs8099917 were not associated with the disease (P > 0.05). 31196204

2019

dbSNP: rs763362
rs763362
0.010 GeneticVariation BEFREE Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076). 31114873

2019

dbSNP: rs8072510
rs8072510
0.010 GeneticVariation BEFREE Neither rs12252 nor rs8072510 showed an association according to the presence of clinical risk factors for influenza complications (P > 0.05), suggesting that these factors did not modify associations between the SNPs and hospitalized influenza. 29053189

2018

dbSNP: rs2476601
rs2476601
0.010 GeneticVariation BEFREE There was no significant difference among healthy pregnant R620W carriers and non-carriers in H1N1 antibody seroconversion rates after influenza vaccination. 28723925

2017