Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE The aim of the current study is to prospectively investigate the impact of the COMT rs4680 polymorphism on the incidence of AKI in patients undergoing cardiac surgery. 29426301

2018

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery. 25525983

2014

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery. 24167357

2013

dbSNP: rs121907892
rs121907892
0.030 GeneticVariation BEFREE We here described a 25-yr-old man showing idiopathic renal hypouricemia with G774A mutation in SCL22A12 who presented exercise-induced acute renal failure. 21935282

2011

dbSNP: rs121907892
rs121907892
0.030 GeneticVariation BEFREE The patient had compound heterozygous mutations in the hURAT1 gene (R90H and W258X), but showed no clinical manifestations such as urolithiasis or exercise-induced acute renal failure. 17362586

2007

dbSNP: rs121907892
rs121907892
0.030 GeneticVariation BEFREE She had compound heterozygous mutations in this gene (W258X and IVS2+1G>A), nevertheless, she showed no clinical manifestations such as urolithiasis and exercise-induced acute renal failure. 16724660

2006

dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in <i>TNFA</i> and rs1800896 in <i>IL10</i> and AKI, we found no association (odds ratios 1.06 (95% CI 0.89⁻1.28, <i>p</i> = 0.51) and 0.92 (95% CI 0.80⁻1.05, <i>p</i> = 0.20), respectively). 30862128

2019

dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE The TNFA rs1800629 gene polymorphism is associated with markers of kidney disease severity and distant organ dysfunction among patients with AKI. 23796916

2013

dbSNP: rs1800896
rs1800896
0.010 GeneticVariation BEFREE Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in <i>TNFA</i> and rs1800896 in <i>IL10</i> and AKI, we found no association (odds ratios 1.06 (95% CI 0.89⁻1.28, <i>p</i> = 0.51) and 0.92 (95% CI 0.80⁻1.05, <i>p</i> = 0.20), respectively). 30862128

2019

dbSNP: rs1800777
rs1800777
0.010 GeneticVariation BEFREE In the Derivation Cohort, one genetic variant in the Cholesteryl Ester Transfer Protein (CETP) gene, rs1800777 (allele A), was strongly associated with lower HDL-C levels (17.4 mg/dL vs. 32.9 mg/dL, P = 0.002), greater CETP mass (3.43 µg/mL vs. 1.32 µg/mL, P = 0.034), and increased risk of clinically significant sepsis-associated AKI (OR: 8.28, p = 0.013). 30425299

2018

dbSNP: rs2233406
rs2233406
0.010 GeneticVariation BEFREE In conclusion, <i>NFKB1</i> rs28362491, <i>NFKBIA</i> rs2233406 and <i>NFKBIA</i> rs696 polymorphisms may serve as biomarkers for predicting risk of AKI in children. 30429237

2018

dbSNP: rs696
rs696
0.010 GeneticVariation BEFREE In conclusion, <i>NFKB1</i> rs28362491, <i>NFKBIA</i> rs2233406 and <i>NFKBIA</i> rs696 polymorphisms may serve as biomarkers for predicting risk of AKI in children. 30429237

2018

dbSNP: rs10854554
rs10854554
0.010 GeneticVariation BEFREE These include rs62341639 (metaanalysis P = 2.48 × 10<sup>-7</sup>; odds ratio [OR], 0.64; 95% confidence interval [CI], 0.55-0.76) and rs62341657 (P = 3.26 × 10<sup>-7</sup>; OR, 0.65; 95% CI, 0.55-0.76) on chromosome 4 near APOL1-regulator IRF2, and rs9617814 (metaanalysis P = 3.81 × 10<sup>-6</sup>; OR, 0.70; 95% CI, 0.60-0.81) and rs10854554 (P = 6.53 × 10<sup>-7</sup>; OR, 0.67; 95% CI, 0.57-0.79) on chromosome 22 near acute kidney injury-related gene TBX1. 27576016

2017

dbSNP: rs1955656
rs1955656
0.010 GeneticVariation BEFREE The SNPs rs2093266 in the SERPINA4 and rs1955656 in the SERPINA5 were associated with the development of severe AKI (KDIGO stage 2-3) in critically ill patients with septic shock. 28270177

2017

dbSNP: rs2093266
rs2093266
0.010 GeneticVariation BEFREE The SNPs rs2093266 in the SERPINA4 and rs1955656 in the SERPINA5 were associated with the development of severe AKI (KDIGO stage 2-3) in critically ill patients with septic shock. 28270177

2017

dbSNP: rs41507953
rs41507953
0.010 GeneticVariation BEFREE The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD. 28552948

2017

dbSNP: rs62341639
rs62341639
0.010 GeneticVariation BEFREE These include rs62341639 (metaanalysis P = 2.48 × 10<sup>-7</sup>; odds ratio [OR], 0.64; 95% confidence interval [CI], 0.55-0.76) and rs62341657 (P = 3.26 × 10<sup>-7</sup>; OR, 0.65; 95% CI, 0.55-0.76) on chromosome 4 near APOL1-regulator IRF2, and rs9617814 (metaanalysis P = 3.81 × 10<sup>-6</sup>; OR, 0.70; 95% CI, 0.60-0.81) and rs10854554 (P = 6.53 × 10<sup>-7</sup>; OR, 0.67; 95% CI, 0.57-0.79) on chromosome 22 near acute kidney injury-related gene TBX1. 27576016

2017

dbSNP: rs62341657
rs62341657
0.010 GeneticVariation BEFREE These include rs62341639 (metaanalysis P = 2.48 × 10<sup>-7</sup>; odds ratio [OR], 0.64; 95% confidence interval [CI], 0.55-0.76) and rs62341657 (P = 3.26 × 10<sup>-7</sup>; OR, 0.65; 95% CI, 0.55-0.76) on chromosome 4 near APOL1-regulator IRF2, and rs9617814 (metaanalysis P = 3.81 × 10<sup>-6</sup>; OR, 0.70; 95% CI, 0.60-0.81) and rs10854554 (P = 6.53 × 10<sup>-7</sup>; OR, 0.67; 95% CI, 0.57-0.79) on chromosome 22 near acute kidney injury-related gene TBX1. 27576016

2017

dbSNP: rs9617814
rs9617814
0.010 GeneticVariation BEFREE These include rs62341639 (metaanalysis P = 2.48 × 10<sup>-7</sup>; odds ratio [OR], 0.64; 95% confidence interval [CI], 0.55-0.76) and rs62341657 (P = 3.26 × 10<sup>-7</sup>; OR, 0.65; 95% CI, 0.55-0.76) on chromosome 4 near APOL1-regulator IRF2, and rs9617814 (metaanalysis P = 3.81 × 10<sup>-6</sup>; OR, 0.70; 95% CI, 0.60-0.81) and rs10854554 (P = 6.53 × 10<sup>-7</sup>; OR, 0.67; 95% CI, 0.57-0.79) on chromosome 22 near acute kidney injury-related gene TBX1. 27576016

2017

dbSNP: rs2276415
rs2276415
0.010 GeneticVariation BEFREE A χ(2)-test and multivariable logistic regression analysis with adjustments for age, sex, baseline serum creatinine, and underlying comorbid disease covariates showed a significant association between rs2276415 and the prevalence of any event of acute kidney injury and chronic kidney disease (CKD) in diabetic patients but not in patients without diabetes. 26719361

2016

dbSNP: rs1050851
rs1050851
0.010 GeneticVariation BEFREE In Caucasian patients, we identified associations between two SNPs and the incidence of AKI (stage 1 and above): rs1050851 and rs2233417; both are found within the gene for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA). 26477820

2015

dbSNP: rs1799983
rs1799983
0.010 GeneticVariation BEFREE Patients with the TT-homozygous genotype of eNOS G894T had more severe PUUV-induced AKI than the other genotypes. 26561052

2015

dbSNP: rs2233417
rs2233417
0.010 GeneticVariation BEFREE In Caucasian patients, we identified associations between two SNPs and the incidence of AKI (stage 1 and above): rs1050851 and rs2233417; both are found within the gene for nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA). 26477820

2015

dbSNP: rs1370328347
rs1370328347
0.010 GeneticVariation BEFREE Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians. 24059882

2014

dbSNP: rs1800470
rs1800470
0.010 GeneticVariation BEFREE To investigate whether the genetic polymorphisms of rs1800470 (codon 10 T/C), rs1800471 (codon 25 C/G) from the TGF-β, and rs2430561 (+874 T/A) from IFN-γ may be a risk factor for ICU patients to the development of AKI and/or death. 25147823

2014