Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated in the sibling pairs and in an additional 92 unrelated African-Americans with type 2 diabetes mellitus-associated ESRD (singletons). 11071967

2000

dbSNP: rs1805087
rs1805087
MTR
0.010 GeneticVariation BEFREE To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects. 11592445

2002

dbSNP: rs5443
rs5443
0.010 GeneticVariation BEFREE Transmission of G-protein beta3 subunit C825T alleles to offspring affected with end-stage renal disease. 11684796

2002

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males. 11823442

2002

dbSNP: rs4961
rs4961
0.020 GeneticVariation BEFREE We examined the influence of the ACE I/D polymorphism, adducin Trp460Gly polymorphism and the association of both polymorphisms on the progression of ADPKD towards end-stage renal failure (ESRF). 12697976

2003

dbSNP: rs3732378
rs3732378
0.020 GeneticVariation BEFREE The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis. 12846758

2004

dbSNP: rs3732379
rs3732379
0.020 GeneticVariation BEFREE The -174G/C polymorphism of the IL-6 gene and the chemokine receptor CX3CR1 polymorphisms 249V/I and 280T/M were examined for their association with cardiovascular abnormalities in a cohort of 161 patients with end-stage renal disease (ESRD) treated by hemodialysis. 12846758

2004

dbSNP: rs397507444
rs397507444
0.030 GeneticVariation BEFREE We genotyped 429 type 2 diabetic patients for the C677T and A1298C polymorphisms using standard PCR-based protocols, and divided them into three groups based on renal status: 159 patients with normoalbuminuria, 149 with microalbuminuria, and 121 with persistent proteinuria and chronic renal failure (CRF). 12897091

2003

dbSNP: rs1801198
rs1801198
0.010 GeneticVariation BEFREE Effect of TCN2 776C>G on vitamin B12 cellular availability in end-stage renal disease patients. 12911562

2004

dbSNP: rs4961
rs4961
0.020 GeneticVariation BEFREE The G460W polymorphism of ADD had no effect on the age at ESRD and cumulative renal survival, either alone or in combination with the ACE (I/D) polymorphism. 13679477

2004

dbSNP: rs6280
rs6280
0.010 GeneticVariation BEFREE Frequencies of the -707 G/C minor genotypes were 35 (normoalbuminuria), 32 (microalbuminuria), 28 (proteinuria) and 39% (end-stage renal disease) (chi(2) = 6.3, df = 3, P = 0.1), of the Ser9Gly 52, 51, 46 and 57% (chi(2) = 6.3, df = 3, P = 0.1) and of the Ala17Ala polymorphism 18, 19, 19 and 21% (chi(2) = 0.7, df = 3, P = 0.9), respectively. 15004255

2004

dbSNP: rs3743930
rs3743930
0.010 GeneticVariation BEFREE None of our patients had amyloidosis but two with E148Q/E148Q had a family history of amyloidosis and one had rapidly progressive glomerulonephritis secondary to vasculitis, which progressed to chronic renal failure. 15458961

2005

dbSNP: rs515299
rs515299
CFH
0.010 GeneticVariation BEFREE In addition, a heterozygous mutation (causing an S890I change) in factor H of complement was found in the patient who developed chronic renal failure but not in her sister, who presented with exclusive neurologic symptoms. 15800115

2005

dbSNP: rs2070600
rs2070600
0.010 GeneticVariation BEFREE Among the three described polymorphisms, only the RAGE Gly82Ser genotype frequency was significantly increased in the group with advanced nephropathy (11%) defined by a chronic renal failure compared to the three others groups: no nephropathy, 5%; incipient (microalbuminuria) 5%; established (macroalbuminuria), 2%) (P=0.04). 15803111

2005

dbSNP: rs1801282
rs1801282
0.040 GeneticVariation BEFREE The aim of this study was to clarify whether the PPAR-gamma 161C/T and PPAR-gamma2 Pro12Ala single-nucleotide polymorphisms (SNPs) influence the inter-individual variance of inflammation and mortality in ESRD patients. 16115480

2006

dbSNP: rs1805192
rs1805192
0.040 GeneticVariation BEFREE The aim of this study was to clarify whether the PPAR-gamma 161C/T and PPAR-gamma2 Pro12Ala single-nucleotide polymorphisms (SNPs) influence the inter-individual variance of inflammation and mortality in ESRD patients. 16115480

2006

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease. 16148605

2005

dbSNP: rs397507444
rs397507444
0.030 GeneticVariation BEFREE In this case-control, cross-sectional study the frequency of the MTHFR 677C --> T and the 1298A --> C polymorphism was compared between patients with hypertension-related chronic renal failure (n = 90), patients with essential hypertension without kidney injury (n = 90), and healthy individuals (n = 90) who were matched for age and gender. 16280279

2005

dbSNP: rs1799983
rs1799983
0.060 GeneticVariation BEFREE Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. 16364824

2006

dbSNP: rs121908525
rs121908525
0.010 GeneticVariation BEFREE In conclusion, in this PH1 population, all bearing the I244T mutation, the development of end-stage renal disease was distinctive during late adolescence or adulthood. 16912707

2006

dbSNP: rs5370
rs5370
0.010 GeneticVariation BEFREE Comparing the ages at the time of ESRD in patients with different 3A/4A and K198N haplotypes, we found a significantly lower age at the time of ESRD (47.1 +/- 8.7 years) in the carriers of the 4A allele in combination with the 198N allele (4A/4A, 3A/4A + 198KN,NN) than in the carriers of the 4A allele homozygous for the K198 allele (52.9 +/- 10.9 years; 4A/4A, 3A/4A + 198KK; t test: p < 0.01) and in the carriers of the 198N allele homozygous for the 3A allele (53 +/- 11.2 years; 3A/3A + 198KN,NN; t test: p < 0.05). 16943682

2006

dbSNP: rs1033182
rs1033182
0.010 GeneticVariation BEFREE The most significant association with type 2 diabetes-ESRD was with rs1033182 in intron 2 (P = 0.013, admixture-adjusted P(a) = 0.021). 17327435

2007

dbSNP: rs1709183
rs1709183
0.010 GeneticVariation BEFREE Two intron 2 SNPs, rs2431260 (P = 0.015) and rs1709183 (P = 0.019), and a four-SNP haplotype containing these SNPs (P = 0.033) were associated with type 2 diabetes and/or ESRD. 17327435

2007

dbSNP: rs2431260
rs2431260
0.010 GeneticVariation BEFREE Two intron 2 SNPs, rs2431260 (P = 0.015) and rs1709183 (P = 0.019), and a four-SNP haplotype containing these SNPs (P = 0.033) were associated with type 2 diabetes and/or ESRD. 17327435

2007

dbSNP: rs1045642
rs1045642
0.010 GeneticVariation BEFREE The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in MDR1 between ESRD patients and healthy controls in the Chinese population to determine whether the alteration of the P-gp function is associated with ESRD. 17376299

2009