Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs699
rs699
AGT
0.090 GeneticVariation BEFREE There was no interaction between age of onset of ESRF and either the angiotensinogen M235T allele or angiotensin 1 receptor A1166C polymorphism. 9291178

1997

dbSNP: rs1267969615
rs1267969615
ACE
0.060 GeneticVariation BEFREE There was no interaction between age of onset of ESRF and either the angiotensinogen M235T allele or angiotensin 1 receptor A1166C polymorphism. 9291178

1997

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The genotype of the MTHFR gene in 106 patients with ESRD was homozygous C677T mutation (VV) in 17 patients (16.1%) and heterozygous (AV) in 63 patients (58.4%); 26 patients (24.5%) did not carry this mutation (AA). 10430972

1999

dbSNP: rs699
rs699
AGT
0.090 GeneticVariation BEFREE The results of this study suggest that ACE gene insertion/deletion and angiotensinogen M235T polymorphisms contribute to the increased risk for the development of CRF, but the magnitude of the effect within subsets of patients with specific etiologies of CRF must be evaluated further. 10916074

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.060 GeneticVariation BEFREE The results of this study suggest that ACE gene insertion/deletion and angiotensinogen M235T polymorphisms contribute to the increased risk for the development of CRF, but the magnitude of the effect within subsets of patients with specific etiologies of CRF must be evaluated further. 10916074

2000

dbSNP: rs145640112
rs145640112
0.010 GeneticVariation BEFREE In addition, an A716C polymorphism in exon 7 resulting in the amino acid change H189P in the A3 domain of the heavy chain was observed in 5 patients belonging to 3 ESRD families. 11031105

2000

dbSNP: rs4253373
rs4253373
0.010 GeneticVariation BEFREE Individually or combined, the allelic variants observed are not statistically associated with ESRD, though in several cases (e.g., H183Q) the small number of people in the population carrying these alleles limits our ability to statistically test for significant association with ESRD. 11031105

2000

dbSNP: rs752390951
rs752390951
0.010 GeneticVariation BEFREE In addition, an A716C polymorphism in exon 7 resulting in the amino acid change H189P in the A3 domain of the heavy chain was observed in 5 patients belonging to 3 ESRD families. 11031105

2000

dbSNP: rs760452842
rs760452842
0.010 GeneticVariation BEFREE In addition, an A716C polymorphism in exon 7 resulting in the amino acid change H189P in the A3 domain of the heavy chain was observed in 5 patients belonging to 3 ESRD families. 11031105

2000

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In addition, a mutation, Glu298Asp, in exon 7 of NOS3 and a 27 bp variable number tandem repeat (VNTR) marker in intron 4 of NOS3 were evaluated in the sibling pairs and in an additional 92 unrelated African-Americans with type 2 diabetes mellitus-associated ESRD (singletons). 11071967

2000

dbSNP: rs699
rs699
AGT
0.090 GeneticVariation BEFREE There was no association between age at onset of ESRD and either M235T or A1166C polymorphism. 11136175

2001

dbSNP: rs1267969615
rs1267969615
ACE
0.060 GeneticVariation BEFREE There was no association between age at onset of ESRD and either M235T or A1166C polymorphism. 11136175

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T mutation of the MTHFR gene may be an independent risk factor that predicts the development of carotid atherosclerosis in ESRD patients. 11287760

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T genotype of MTHFR is associated with CVD in ESRD and may be a more meaningful marker than tHcy for abnormal homocysteine metabolism in ESRD. 11532106

2001

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects. 11592445

2001

dbSNP: rs1805087
rs1805087
MTR
0.010 GeneticVariation BEFREE To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects. 11592445

2001

dbSNP: rs370819889
rs370819889
ALB
0.010 GeneticVariation BEFREE To evaluate the respective roles of residual glomerular filtration (by measuring a specific protein marker, cystatin C), genetic polymorphisms and nutritional status in tHcy blood levels in end-stage renal disease patients (ESRD) under hemodialysis and supplemented with folate, we measured tHcy, folate, vitamin B12 (B12), creatinine, cystatin C, albumin and C-reactive protein and determined the polymorphism of methylenetetrahydrofolate reductase (MTHFR) (C677T and A1289C) and of methionine synthase (MS) (A2756G) in 114 ESRD patients before hemodialysis and 76 control subjects. 11592445

2001

dbSNP: rs5443
rs5443
0.020 GeneticVariation BEFREE The results of our study suggest that GNB3 C825T polymorphism does not contribute substantially to the increased risk of the development of ESRD. 11684796

2002

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE In conclusion, the frequent Glu298Asp polymorphism of ENOS is associated with a 5 year lower mean age at ESRD in this subset of ADPKD males. 11823442

2002

dbSNP: rs1042636
rs1042636
0.020 GeneticVariation BEFREE Our results suggest that CaR gene polymorphism (codon G990R) influences the responsiveness of the parathyroid gland to changes of extracellular Ca2+ in ESRD patients. 11863123

2002

dbSNP: rs5443
rs5443
0.020 GeneticVariation BEFREE In conclusion, in a sizeable number of pediatric renal transplant recipients the GNB3 C825T polymorphism was found not to be a genetic risk factor for end-stage kidney disease. 12000471

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our results did not show any association between the MTHFR reductase C677T polymorphism and the increased risk of the development of end-stage renal disease. 12187113

2002

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE These data indicated that Glu298Asp is the predisposing factor in ESRD, especially DM-derived ESRD. 12364359

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The combined effects of renal failure, folate and vitamin B(12) levels, and a common mutation (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene that leads to total plasma homocysteine (tHcy) elevation in CRF children were investigated. 12644913

2003

dbSNP: rs699
rs699
AGT
0.090 GeneticVariation BEFREE Two hundred and forty-six end-stage renal disease (ESRD) patients on peritoneal dialysis and 183 control subjects, all of Chinese origin, were genotyped for the ACE insertion/deletion (I/D) and the AGT M235T gene polymorphisms. 12675870

2003