Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4961
rs4961
0.020 GeneticVariation BEFREE The G460W polymorphism of ADD had no effect on the age at ESRD and cumulative renal survival, either alone or in combination with the ACE (I/D) polymorphism. 13679477

2004

dbSNP: rs4961
rs4961
0.020 GeneticVariation BEFREE We examined the influence of the ACE I/D polymorphism, adducin Trp460Gly polymorphism and the association of both polymorphisms on the progression of ADPKD towards end-stage renal failure (ESRF). 12697976

2003

dbSNP: rs10951982
rs10951982
0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219

2016

dbSNP: rs12431381
rs12431381
0.010 GeneticVariation BEFREE An all-cause ESKD association analysis contrasted the 3,594 AA ESKD cases with 1,489 AA non-nephropathy controls and detected association with rs12434215 (p=6.7×10(-4), OR 0.73) and rs12431381 (p=7.5×10(-4), OR 0.75) in dominant models. 26496126

2016

dbSNP: rs12434215
rs12434215
0.010 GeneticVariation BEFREE An all-cause ESKD association analysis contrasted the 3,594 AA ESKD cases with 1,489 AA non-nephropathy controls and detected association with rs12434215 (p=6.7×10(-4), OR 0.73) and rs12431381 (p=7.5×10(-4), OR 0.75) in dominant models. 26496126

2016

dbSNP: rs1800469
rs1800469
0.010 GeneticVariation BEFREE Our results conclude that TGF-β1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-β1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir. 25871499

2016

dbSNP: rs1800470
rs1800470
0.010 GeneticVariation BEFREE Our results conclude that TGF-β1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-β1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir. 25871499

2016

dbSNP: rs1952034
rs1952034
0.010 GeneticVariation BEFREE Three intronic RTN1 variants were nominally associated with T2D-ESKD in both discovery and replication analyses: rs1952034, rs12431381 and rs12434215 (additive models); combined T2D-ESKD (discovery+replication) p values were 0.015-3.0×10(-4) (ORs 0.67-0.77; minor alleles protective). 26496126

2016

dbSNP: rs3448
rs3448
0.010 GeneticVariation BEFREE The minor T-allele of rs3448 was associated with kidney complications (incidences of microalbuminuria, renal events and ESRD) in patients with type 1 diabetes. 26773925

2016

dbSNP: rs4880
rs4880
0.010 GeneticVariation BEFREE Regression analysis showed that TT genotype of SOD2 Val16Ala conferred significantly lower ESRD risk among patients without diabetes (odds ratio 0.699; p = 0.018).GPX1 SNP alone did not alter the risk. 26881045

2016

dbSNP: rs6954996
rs6954996
0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219

2016

dbSNP: rs702483
rs702483
0.010 GeneticVariation BEFREE In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05). 26841219

2016

dbSNP: rs743811
rs743811
0.010 GeneticVariation BEFREE HMOX1 rs743811 associated with chronic kidney disease stage (OR=3.0, P=0.0001) in the University of Illinois cohort and end-stage renal disease (OR=10.0, P=0.0003) in the Walk-Treatment of Pulmonary Hypertension and Sickle cell Disease with Sildenafil Therapy cohort. 26206798

2016

dbSNP: rs758815179
rs758815179
0.010 GeneticVariation BEFREE We prospectively enrolled multicenter patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-γ (Pro12Ala, C161T) genotyped. 26881045

2016

dbSNP: rs836488
rs836488
0.010 GeneticVariation BEFREE In addition, these three SNPs also had associations with increased ESRD risk under the additive model (P < 0.05), and positive associations were also found for the rs836488 in the dominant model (P < 0.05) and for the rs702483 in the recessive model (P < 0.05). 26841219

2016

dbSNP: rs9374
rs9374
0.010 GeneticVariation BEFREE The other three SNPs (rs10951982, rs6954996, and rs9374), in all comparison models, were not associated with ESRD risk (P > 0.05). 26841219

2016

dbSNP: rs115489112
rs115489112
0.010 GeneticVariation BEFREE Two additional variants (H800R and Y1174H) were nominally associated with protection from end stage renal disease (P=0.036; odds ratio, 0.44; P=0.0084; odds ratio, 0.040, respectively) in the locus-wide single-variant association tests. 24948143

2015

dbSNP: rs11614913
rs11614913
0.010 GeneticVariation BEFREE These results suggest that the variants of MicroRNA SNPs, namely, rs2910164, rs11614913, and rs3746444, might be involved in susceptibility to ESRD and AR. 24978643

2015

dbSNP: rs12137135
rs12137135
0.010 GeneticVariation BEFREE An association between ESRD and rs17709344, tagging the previously identified rs12437854 and located between the RGMA and MCTP2 genes, was replicated in independent case-control cohorts. rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno. 24871321

2015

dbSNP: rs12917114
rs12917114
0.010 GeneticVariation BEFREE An association between ESRD and rs17709344, tagging the previously identified rs12437854 and located between the RGMA and MCTP2 genes, was replicated in independent case-control cohorts. rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno. 24871321

2015

dbSNP: rs146400394
rs146400394
0.010 GeneticVariation BEFREE Two additional variants (H800R and Y1174H) were nominally associated with protection from end stage renal disease (P=0.036; odds ratio, 0.44; P=0.0084; odds ratio, 0.040, respectively) in the locus-wide single-variant association tests. 24948143

2015

dbSNP: rs1670754
rs1670754
0.010 GeneticVariation BEFREE Five genetic loci (WNT4/ZBTB40-rs12137135, RGMA/MCTP2-rs17709344, MAPRE1P2-rs1670754, SEMA6D/SLC24A5-rs12917114 and SIK1-rs2838302) were associated with ESRD in the FinnDiane study. 24871321

2015

dbSNP: rs17709344
rs17709344
0.010 GeneticVariation BEFREE An association between ESRD and rs17709344, tagging the previously identified rs12437854 and located between the RGMA and MCTP2 genes, was replicated in independent case-control cohorts. rs12917114 near SEMA6D was associated with ESRD in the replication cohorts under the genotypic model (p < 0.05), and rs12137135 upstream of WNT4 was associated with ESRD in Steno. 24871321

2015

dbSNP: rs2292832
rs2292832
0.010 GeneticVariation BEFREE Subsequently, no susceptible/protective effect was observed for rs2292832 SNP with ESRD and AR cases. 24978643

2015

dbSNP: rs2802723
rs2802723
0.010 GeneticVariation BEFREE The minor allele in NPHS2 markedly changed the APOL1-ESKD association odds ratio (OR) from 7.03 to 1.76 (∼50% reduction in effect per copy of the minor allele), rs2802723 changed the OR from 5.1 to 10.5, and rs8014363 increased the OR from 4.8 to 9.5. 24157943

2015