Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | We conclude that heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci correlate significantly with ESRD in a north Indian population. | 25660845 | 2015 |
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0.090 | GeneticVariation | BEFREE | Furthermore, there was no a markedly positive association between AGT M235T gene polymorphism and ESRD susceptibility in overall populations, Asians and Africans. | 23065231 | 2013 |
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0.090 | GeneticVariation | BEFREE | This study was designed to evaluate the angiotensin-converting enzyme insertion/deletion (ACE-I/D), angiotensinogen (AGT) M235T, and angiotensin II receptor type 1 (ATR1) A1166C and type 2 (ATR2) C3123A gene polymorphisms as risk factors for progression to ESRD in patients with VUR.Methods. | 19288324 | 2009 |
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0.090 | GeneticVariation | BEFREE | Two hundred and forty-six end-stage renal disease (ESRD) patients on peritoneal dialysis and 183 control subjects, all of Chinese origin, were genotyped for the ACE insertion/deletion (I/D) and the AGT M235T gene polymorphisms. | 12675870 | 2003 |
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0.090 | GeneticVariation | BEFREE | We studied retrospectively the role of angiotensinogen (AGT) M235T, angiotensin converting enzyme (ACE) insertion/deletion (I/D), angiotensin II type 1 receptor (AT1R) A1166C, aldosterone syntase (CYP11B2) -344C/T and intron 2 W/C polymorphisms in conjunction with clinical and biochemical covariables on the rate of progression of renal insufficiency in a group of patients with ESRD of various etiologies. | 12832734 | 2003 |
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0.090 | GeneticVariation | BEFREE | There were no differences in the prevalence of hypertension and the ages at the ESRD in relation to the AGT M235T and ATR A1166C polymorphisms. | 12950120 | 2003 |
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0.090 | GeneticVariation | BEFREE | There was no association between age at onset of ESRD and either M235T or A1166C polymorphism. | 11136175 | 2001 |
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0.090 | GeneticVariation | BEFREE | The results of this study suggest that ACE gene insertion/deletion and angiotensinogen M235T polymorphisms contribute to the increased risk for the development of CRF, but the magnitude of the effect within subsets of patients with specific etiologies of CRF must be evaluated further. | 10916074 | 2000 |
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0.090 | GeneticVariation | BEFREE | There was no interaction between age of onset of ESRF and either the angiotensinogen M235T allele or angiotensin 1 receptor A1166C polymorphism. | 9291178 | 1997 |